Dopaminergic regulation of gonadotrophin secretion in seasonally anoestrous mares

Journal of Reproduction and Fertility
B BesognetP Daels

Abstract

We have previously demonstrated that daily administration of the dopamine D2 antagonist, sulpiride, during seasonal anoestrus, effectively advances the mean time of onset of the breeding season in mares. The purpose of this study was to examine the effect of sulpiride administration on pulsatile FSH and LH secretion in seasonally anoestrous mares, follicular development, time of first ovulation and the fertility at the first ovulation. Fourteen anoestrous mares were selected based on progesterone concentrations < 1 ng ml-1 for 3 weeks and largest follicle diameter < 20 mm. Starting 30 January, eight seasonally anoestrous mares were treated daily with sulpiride until the first ovulation of the year, and six untreated control mares were maintained under the same environmental conditions. Ovarian activity was monitored and plasma samples were collected every other day. On days 1, 11 and 21 of treatment, plasma samples were collected every 15 min for 11 h in six treated and six control mares. Mares were bred during the first oestrus. Mean time of first ovulation was significantly advanced in sulpiride-treated mares compared with control mares. Pregnancy rate 18 days after ovulation was similar between groups. Mean FSH pulse frequen...Continue Reading

Citations

Apr 14, 2005·Domestic Animal Endocrinology·S S KingK L Jones
Jun 14, 2000·Animal Reproduction Science·N Parvizi
Jun 14, 2000·Animal Reproduction Science·P NagyP Daels
May 13, 2014·Theriogenology·B WespiD Burger
Sep 3, 2003·Reproduction in Domestic Animals = Zuchthygiene·D GuillaumeP F Daels
Aug 3, 2006·The Veterinary Clinics of North America. Equine Practice·Kristina G Lu, Peter R Morresey
Oct 22, 1998·Biology of Reproduction·L A DavisonB P Fitzgerald
Mar 27, 2020·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Tina L DowJanine L Brown
May 6, 2019·Reproduction in Domestic Animals = Zuchthygiene·Pouya DiniPeter Daels
Oct 22, 2020·Animals : an Open Access Journal From MDPI·Katiuska SatuéPietro Medica

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