Dopaminergic regulation of olfactory type G-protein α subunit expression in the striatum

Movement Disorders : Official Journal of the Movement Disorder Society
I Ruiz-DeDiegoR Moratalla

Abstract

In rodents, the olfactory type G-protein α subunit (Gαolf) couples the dopamine D1 receptor (D1R) to adenylyl cyclase, triggering intracellular signaling and neuronal activation. In the striatum, Gαolf is enriched in the striosomes. Changes in Gαolf protein levels have been observed after dopamine depletion. However, the regulation of Gαolf expression by dopamine and dopamine receptors is not fully understood. To address this, Striatal Gαolf expression pattern was studied in wild-type and genetically engineered mice lacking D1R, D2R (D2 receptor), and downstream regulatory element antagonist modulator (DREAM) protein whose dopamine levels were manipulated. Dopamine depletion was accomplished by 6-hydroxydopamine (6-OHDA) or by Pitx3 ablation, and dopamine replacement by chronic levodopa (l-dopa). The Gαolf levels were analyzed by immunohistochemistry, Western blot, and real-time quantitative polymerase chain reaction (RT-qPCR). Our results demostrate that Dopamine depletion or inactivation of D1R abolished the striosomal pattern of Gαolf expression and increased Gαolf protein levels. Dopamine replacement in wild-type lesioned mice reestablished both the expression pattern and protein levels, but paradoxically increased Gαolf me...Continue Reading

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Citations

Oct 9, 2015·Journal of Receptor and Signal Transduction Research·B J LaoyeO M Ogundele
Oct 13, 2015·Progress in Neurobiology·Rosario MoratallaMicaela Morelli
Jul 5, 2016·Neurobiology of Disease·Maurício Dos-Santos-PereiraElaine Del-Bel
Jul 28, 2016·Frontiers in Aging Neuroscience·Isidro FerrerStefano Gustincich
Sep 2, 2016·Neurotoxicity Research·Gabriel Henrique HawthorneElaine Del-Bel
Nov 3, 2016·Pharmaceutical Patent Analyst·Hermann Am Mucke
Mar 7, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Goichi BeckStella M Papa
Mar 9, 2018·Cell and Tissue Research·Hana YouJean-Christophe Corvol
Feb 6, 2018·Journal of Neural Transmission·Giada Spigolon, Gilberto Fisone
Jun 21, 2018·The European Journal of Neuroscience·Tanuja Bordia, Xiomara A Perez
Jul 10, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Luz M SuarezRosario Moratalla

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