PMID: 6402628Jan 24, 1983Paper

Dopaminergic supersensitivity at distant sites following induced epileptic foci

Life Sciences
J G CsernanskyL E Hollister

Abstract

Injection of ferric chloride (FeCl3) into the left amygdaloid nucleus of the rat produced partial complex seizures. Subsequent repeated apomorphine challenges revealed steady development of behavioral dopaminergic supersensitivity, above that observed in saline-injected controls. The behavioral supersensitivity observed in FeCl3-injected animals was accompanied by increases in 3H-spiroperidol binding in contralateral amygdala, striatum and ipsilateral nucleus accumbens. In contrast, saline-injected controls demonstrated bilateral decreases in 3H-spiroperidol binding in amygdala and striatum. The effects of FeCl3 injection on the behavioral dopaminergic supersensitivity and 3H-spiroperidol binding were eliminated when the anterior commissure was severed.

References

Jan 1, 1978·Neurology·J R Stevens, A Livermore
Aug 16, 1974·Science·B ZimmerbergT P Jerussi

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Citations

Dec 1, 1991·Neurochemical Research·K F Swaiman, V L Machen
Jul 1, 1985·Biological Psychiatry·J G CsernanskyL E Hollister
Feb 1, 1990·Biological Psychiatry·R E Adamec
Sep 17, 1991·European Journal of Pharmacology·D Ben-ShacharM B Youdim
Mar 11, 1994·European Journal of Pharmacology·S YehudaD I Mostofsky
Feb 1, 1996·Physiology & Behavior·T J SobotkaC N Barton
Sep 1, 1992·Progress in Neuro-psychopharmacology & Biological Psychiatry·P Sachdev
Jan 1, 1986·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·D Ben-ShacharM B Youdim
Jan 1, 1988·Schizophrenia Research·J R Stevens
Jul 1, 1995·Schizophrenia Research·M F CasanovaM Kruesi
Oct 24, 2003·Psychiatry Research·Manuel F Casanova, Julio M Araque
Jun 1, 1992·The Japanese Journal of Psychiatry and Neurology·J A Wada
Jul 23, 1999·Annals of the New York Academy of Sciences·J R Stevens
Aug 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·A BartonK Ebmeier
Sep 23, 1998·Experimental Neurology·Y UedaW J Triggs
Oct 1, 1985·Journal of Neurochemistry·D Ben-ShacharM B Youdim
Oct 1, 1987·The British Journal of Psychiatry : the Journal of Mental Science·T J Crow
Feb 1, 1988·Biological Psychiatry·J G CsernanskyL Lombrozo

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