Dopaminergic supersensitivity factors in Tourette's syndrome: a hypothesis

The International Journal of Neuroscience
R Sandyk

Abstract

Alterations in striatal dopamine receptor functions are thought to underlie the major symptoms of Tourette's syndrome (TS). In this communication, evidence is presented to suggest that the striatal dopamine receptor supersensitivity in TS may be mediated by alterations in the release and function of dopamine supersensitive factors including prolactin, estrogens, beta-endorphin, melanocyte stimulating hormone (MSH), and adrenal corticotrophic hormone (ACTH). It is suggested that treatment of TS should be directed towards rectifying these endocrine and neuropeptide imbalances.

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Citations

Jun 15, 1992·Biological Psychiatry·F R SalleeI Hanin
May 8, 2004·Behavioural Brain Research·Ana L Jongen-RêloJoram Feldon
Jan 1, 1990·The International Journal of Neuroscience·R Sandyk
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