Doping of carbon nanodots for saving cells from silver nanotoxicity: A study on recovering osteogenic differentiation potential

Toxicology in Vitro : an International Journal Published in Association with BIBRA
Bodhisatwa DasSantanu Dhara

Abstract

Silver nanoparticles are explored for many advanced biological applications including the development of antimicrobial surfaces on implants, SERS imaging, nanotherapeutics, biosensing and much more. However, recent research findings suggest silver nanoparticles provide blockade of differentiation of mesenchymal stem cells (MSCs), especially into osteogenic developmental pathway via generation of reactive oxygen species. These studies suggest that the application of silver nanoparticles in medical implants should be prohibited. In the current study, carbon nanodots (CND) supported silver clusters (AgC) is explored as a remedy to this problem. The nanostructure was synthesized in microwave irradiation induced rapid method and characterization was conducted via UV-Vis spectroscopy, fluorescence spectroscopy, HRTEM, XRD, FTIR, Raman spectroscopy, DLS, AFM, and XPS. Fluorescence spectrum showed a quantum yield of 0.25 while Raman spectroscopy showed rapid amplification of CND specific peaks implicating significant SERS property. Further in vitro biocompatibility (MTT) and bio-imaging capability was assessed culturing Wharton's Jelly-derived MSCs. In this study, its efficacy as in-situ cellular oxidative stress scavenger is also stud...Continue Reading

Citations

Jan 25, 2020·Advanced Healthcare Materials·Zhili PengRoger M Leblanc
Nov 2, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·You ZhouZhouping Wang

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