Doping the Mind: Dopaminergic Modulation of Prefrontal Cortical Cognition

The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry
Ajit Ranganath, Simon N Jacob

Abstract

The prefrontal cortex is the center of cognitive control. Processing in prefrontal cortical circuits enables us to direct attention to behaviorally relevant events; to memorize, structure, and categorize information; and to learn new concepts. The prefrontal cortex receives strong projections from midbrain neurons that use dopamine as a transmitter. In this article, we review the crucial role dopamine plays as a modulator of prefrontal cognitive functions, in the primate brain in particular. Following a summary of the anatomy and physiology of the midbrain dopamine system, we focus on recent studies that investigated dopaminergic effects in prefrontal cortex at the cellular level. We then discuss how unregulated prefrontal dopamine signaling could contribute to major disorders of cognition. The studies highlighted in this review demonstrate the powerful influence dopamine exerts on the mind.

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Citations

Jul 19, 2016·Neuropsychologia·Rachel Rac-Lubashevsky, Yoav Kessler
Jan 31, 2019·The Journal of Comparative Neurology·Shankhamala SenSoumya Iyengar
May 1, 2018·Frontiers in Neuroscience·David A Vogelsang, Mark D'Esposito
Feb 28, 2018·Frontiers in Neural Circuits·Adrienne MuellerTirin Moore
Jun 2, 2017·Scientific Reports·Rachel Rac-LubashevskyYoav Kessler
May 4, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Laura SerraMarco Bozzali
May 25, 2021·Frontiers in Neuroscience·Denise Elfriede Liesa Lockhofen, Christoph Mulert
Jul 3, 2021·Nature Reviews. Disease Primers·Dag AarslandDaniel Weintraub

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