Doppler echocardiography distinguishes between physiologic and pathologic "silent" mitral regurgitation in patients with rheumatic fever

Clinical Cardiology
L L MinichL G Veasy

Abstract

The diagnosis of rheumatic fever is based on physical findings (major) and supporting laboratory evidence (minor) as defined by the Jones criteria. Rheumatic carditis is characterized by auscultation of a mitral regurgitant murmur. Doppler echocardiography, however, may detect mitral regurgitation when there is no murmur ("silent" mitral regurgitation), even in normal individuals. The hypothesis of this study was that physiologic mitral regurgitation can be differentiated from pathologic "silent" mitral regurgitation by Doppler echocardiography. The study group consisted of 68 patients (2-27 years) with normal two-dimensional imaging and Doppler evidence of mitral regurgitation but no murmur. Patients with rheumatic fever (n = 37) met Jones criteria (chorea in 20, arthritis in 17). Patients without rheumatic fever (n = 31) were referred for innocent murmur (n = 7), abnormal electrocardiogram (n = 13), and chest pain (n = 11). Echoes were independently reviewed by two cardiologists blinded to the diagnosis. Pathologic mitral regurgitation was defined as meeting the following four criteria: (1) length of color jet > 1 cm, (2) color jet identified in at least two planes, (3) mosaic color jet, and (4) persistence of the jet through...Continue Reading

References

Aug 1, 1986·The American Journal of Cardiology·W KostuckiM Englert
Jun 2, 1995·International Journal of Cardiology·N J Wilson, J M Neutze

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Citations

Dec 25, 2007·Pediatric Cardiology·Ahsan Beg, Masood Sadiq
Sep 29, 2011·Pediatric Cardiology·Murat Muhtar YilmazerIlker Devrim
Jan 31, 2004·The Journal of Emergency Medicine·Ghazala Q Sharieff, Todd W Wylie
Aug 3, 2007·The New England Journal of Medicine·Eloi MarijonXavier Jouven
Aug 21, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G H Stollerman
Jul 25, 2000·Clinical Microbiology Reviews·M W Cunningham
May 12, 2001·Infection and Immunity·A QuinnM W Cunningham
Nov 7, 2012·Annals of Pediatric Cardiology·Fátima Derlene da Rocha AraújoZilda Maria Alves Meira
Dec 17, 2010·Cardiovascular Journal of Africa·O OzdemirF S Tunaoglu
May 18, 2016·Nature Reviews. Disease Primers·Jonathan R CarapetisLiesl Zühlke
Mar 13, 2012·Lancet·Eloi MarijonXavier Jouven
Jun 12, 2010·The American Journal of Cardiology·John A PaarJames B Dale
Apr 4, 2007·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Francesco CardonaGraziella Orefici
Aug 25, 2007·Annals of Tropical Paediatrics·Ajit RayamajhiUrmila Shakya
Mar 15, 2005·International Journal of Pediatric Otorhinolaryngology·Aysenur PacDavut Aktas
Oct 13, 2006·International Journal of Cardiology·Marissa Tubridy-Clark, Jonathan R Carapetis
Jul 12, 2005·Lancet·Jonathan R CarapetisNigel J Wilson
Mar 6, 2003·Neurologic Clinics·William M McMahonJenise Jensen
Mar 23, 2002·The American Journal of Cardiology·David A DanfordCarl H Gumbiner
Aug 16, 2016·International Journal of Cardiology·Keishi MoriwakiMasaaki Ito
Nov 26, 2016·Cardiology Clinics·Shanti NuluGene F Kwan
Jun 4, 2004·The Journal of International Medical Research·B S CebeciE Demiralp
Apr 30, 2003·Japanese Heart Journal·Motonori HayashiKeishi Kubo
Mar 7, 2000·Pediatrics International : Official Journal of the Japan Pediatric Society·S KaraaslanI Erkul
Apr 25, 2015·Circulation·Michael H GewitzUNKNOWN American Heart Association Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the Council on Cardiovascular
Nov 6, 2002·Circulation·Patricia Ferrieri, UNKNOWN Jones Criteria Working Group
Feb 19, 2008·Pediatrics International : Official Journal of the Japan Pediatric Society·Vedide TavliFüsun Atlihan
May 2, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Ajit RayamajhiUrmila Shakya
Sep 3, 2017·Echo Research and Practice·L D HunterP G Herbst
Jul 16, 2021·European Heart Journal·Eloi MarijonDavid S Celermajer

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