Doppler velocimetry and thrombophilic screening at middle trimester of gestation: preliminary data

European Journal of Obstetrics, Gynecology, and Reproductive Biology
L Delle ChiaieE Vadora

Abstract

To establish whether asymptomatic normotensive pregnant women with an abnormal uterine Doppler velocimetry, have haematological changes characteristic of congenital or acquired thrombophilia, and whether this information improve predict in pregnancy complications. A prospective study involved the enrolment of 30 healthy normotensive pregnant women between the 23rd and 27th week of gestation, subdivided into group A (normal uterine Doppler velocimetry) and group B (abnormal uterine Doppler velocimetry). Besides uterine velocimetry (resistence index and presence/absence of notch), at enrolment in the study the PI of the umbilical artery and of the middle cerebral artery were measured, in addition to the usual foetal biometric parameters (biparietal diameter and abdominal circumference). Contemporaneously, a 20 ml blood sample was taken for the dosage of protein C, protein S, antithrombin III, activated protein C resistance, antiphospholipid antibodies and platelet functionality. Subsequently, for all the remaining period of the pregnancy, data were collected relating to the onset of any materno-foetal complications and modality of delivery, as well as neonatal data up to the first 20 days of life. The incidence of adverse perinat...Continue Reading

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Citations

Feb 22, 2002·Prenatal Diagnosis
Apr 25, 2012·Archives of Gynecology and Obstetrics·Tayfun CokCantekin Iskender
Mar 24, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Eva López-QuesadaJosep M Lailla
Mar 5, 2005·American Journal of Obstetrics and Gynecology·Heather E A HowleyMarc A Rodger

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Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

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