Doppler velocimetry of growth-restricted fetuses in an ovine model of placental insufficiency

American Journal of Obstetrics and Gynecology
H L GalanF C Battaglia

Abstract

With an ovine model in which growth restriction was induced by exposure to heat stress, our aims were as follows: (1) to describe the normal gestational age-related changes in Doppler velocimetry in the ovine fetal aorta and umbilical artery and (2) to compare Doppler velocimetry between heat-stressed and non-heat-stressed fetuses. Five ewes were exposed to heat stress for 55 days beginning at 35 days' gestation. Five ewes were not exposed and served as controls. Aortic and umbilical artery pulsed Doppler velocimetry was obtained, including the systolic/diastolic ratio, pulsatility index, and resistance index. Data were obtained between 50 and 120 days' gestation. Linear regression analysis was used to analyze gestational age-related changes in velocimetry. Comparison of mean index values between heat-stressed and non-heat-stressed fetuses were made with analysis of variance. Heat-stressed fetuses demonstrated significantly higher systolic/diastolic ratios and pulsatility index values for both umbilical artery (p < 0.025; p < 0.033) and aorta (p < 0.017; p < 0.022) compared with controls. The umbilical artery and aortic resistance index values were not different between groups (p < 0.079; p < 0.28). The slopes for each of the D...Continue Reading

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Citations

May 11, 2004·The Journal of Physiology·Hyung-Chul HanThomas R Hansen
Apr 30, 2002·Placenta·T R H RegnaultR V Anthony
Jul 31, 2012·American Journal of Obstetrics and Gynecology·David J CarrJacqueline M Wallace
Oct 2, 2007·American Journal of Obstetrics and Gynecology·Bradley T ZiebellJuan A Arroyo
Aug 1, 2006·American Journal of Obstetrics and Gynecology·Juan A ArroyoHenry L Galan
May 18, 1999·American Journal of Obstetrics and Gynecology·H L GalanF C Battaglia
Jul 20, 1999·American Journal of Obstetrics and Gynecology·A BarberaG Pardi
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Mar 3, 2006·Expert Review of Cardiovascular Therapy·Paramjit S Tappia, Cindy A Gabriel
Dec 2, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Caleb O LemleyKimberly A Vonnahme
Aug 1, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Laura D BrownStephanie R Wesolowski
Feb 16, 2021·Journal of Animal Science and Biotechnology·William H E J van WettereSimon K Walker
Apr 29, 2020·Reproductive Biology·Manuel Alexander Vasquez-HidalgoKimberly Ann Vonnahme
Aug 8, 2021·International Journal of Molecular Sciences·Amelia R TannerRussell V Anthony

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