PMID: 25751007Mar 10, 2015Paper

Dormant Circulating Tumor Cells In Prostate Cancer: Biological, Clinical And Therapeutic Implications

Current Drug Targets
M J Alvarez-CuberoM J Serrano

Abstract

Circulating Tumor Cells (CTCs) are a valuable prognostic factor in several solid tumors. By understanding their biological properties we could better know the biology of the metastatic process. CTCs usually present a dormant state that is believed to be a strategy to survive under extreme conditions. To enter a dormant state, CTCs undergo numerous phenotypic, genetic and functional mutations. Given that these changes have a significant impact on the efficacy of therapies used to eliminate dormant CTCs, analyzing the biological events involved in the dormancy process of CTCs could be key to the development of new therapeutic targets. Some experimental studies or preclinical models have explored these biological events, as well as the molecular factors that contribute to the maintenance and release from dormancy. However, few studies have assessed the effects of therapies on dormant cells. This review describes current knowledge about cellular dormancy mechanisms in prostate cancer, with a special focus on the functional, genetic and phenotypic plasticity of CTCs and its potential implications for the clinical and therapeutic management of prostate cancer.

Citations

Nov 16, 2017·Calcified Tissue International·Rachelle W Johnson, Larry J Suva
Feb 1, 2018·Proceedings of the Institution of Mechanical Engineers. Part C. Journal of Mechanical Engineering Science·Jifu TanYaling Liu

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