Dorsal cochlear nucleus response properties following acoustic trauma: response maps and spontaneous activity.

Hearing Research
Wei-Li Diana Ma, Eric D Young

Abstract

Recordings from single neurons in the dorsal cochlear nucleus (DCN) of unanesthetized (decerebrate) cats were done to characterize the effects of acoustic trauma. Trauma was produced by a 250 Hz band of noise centered at 10 kHz, presented at 105-120 dB SPL for 4h. After a one-month recovery period, neurons were recorded in the DCN. The threshold shift, determined from compound action-potential audiograms, showed a sharp threshold elevation of about 60 dB at BFs above an edge frequency of 5-10 kHz. The response maps of neurons with best frequencies (BFs) above the edge did not show the typical organization of excitatory and inhibitory areas seen in the DCN of unexposed animals. Instead, neurons showed no response to sound, weak responses that were hard to tune and characterize, or "tail" responses, consisting of broadly-tuned, predominantly excitatory responses, with a roughly low-pass shape similar to the tuning curves of auditory nerve fibers with similar threshold shifts. In some tail responses whose BFs were near the edge of the threshold elevation, a second weak high-frequency response was seen that suggests convergence of auditory nerve inputs with widely separated BFs on these cells. Spontaneous rates among neurons with e...Continue Reading

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Citations

Oct 16, 2008·Journal of the Association for Research in Otolaryngology : JARO·Shanqing CaiEric D Young
Nov 11, 2011·Journal of Neurophysiology·Wei-Li Diana Ma, Stephan D Brenowitz
Sep 27, 2014·Journal of the Association for Research in Otolaryngology : JARO·Tessa-Jonne F RoppBradford J May
Dec 18, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Seth D Koehler, Susan E Shore
Jan 17, 2012·Hearing Research·James B Snow
Apr 30, 2011·Hearing Research·Hongning WangDonald M Caspary
Jun 19, 2014·Journal of Neuroscience Research·Hao LuoJinsheng Zhang
Oct 1, 2014·Cell and Tissue Research·Jos J Eggermont, Larry E Roberts
Jun 7, 2014·Frontiers in Neuroscience·Joshua R Gold, Victoria M Bajo
May 29, 2016·Hearing Research·Jos J Eggermont
Jan 3, 2018·Journal of the Association for Research in Otolaryngology : JARO·Aikeen Jones, Bradford J May
Dec 5, 2019·The Journal of the Acoustical Society of America·Jinsheng Zhang
Feb 20, 2015·Journal of Neurophysiology·Joshua J Sturm, Catherine J C Weisz
Nov 30, 2016·Frontiers in Aging Neuroscience·Jos J Eggermont

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