Dorsal hippocampal involvement in appetitive trace conditioning and interval timing

Behavioral Neuroscience
Shu K E Tam, Charlotte Bonardi

Abstract

Involvement of the dorsal hippocampus (DHPC) in acquisition of Pavlovian trace conditioning and interval timing was examined in an appetitive preparation in which presentations of one conditioned stimulus (CS) were immediately followed by food (delay conditioning), and presentations of another CS were followed by food 15 seconds after its termination (trace conditioning). DHPC lesions did not disrupt acquisition of trace conditioning, but they selectively affected the distribution of conditioned responding over the course of the trace CS in the early stage of acquisition. In addition, lesions disrupted accuracy of timing the conditioned response (CR) for both delay and trace CSs: The control subjects showed maximum CR at the time of food delivery, but in the DHPC-lesioned subjects, the maximum CR was at an earlier time point. This timing deficit did not seem to be due to impulsive responding or deficits in response inhibition because, when the early portion of the delay CS was interrupted shortly by an empty interval, the difference in the time of maximum responding between the lesioned and control subjects was eliminated. Thus, although the involvement of the DHPC in appetitive trace conditioning was not found when a gross mea...Continue Reading

Citations

Apr 12, 2002·Behavioural Processes·Kimberly Kirkpatrick
Jan 22, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Bin Yin, Warren H Meck
Dec 25, 2012·Cognitive, Affective & Behavioral Neuroscience·Abhishek T HarithaDavid C Knight
Sep 17, 2013·Behavioural Processes·Jonathan D Raybuck, K Matthew Lattal
Mar 1, 2012·Behavioural Brain Research·Shu K E Tam, Charlotte Bonardi
Aug 16, 2016·Neurobiology of Learning and Memory·Yutaka Kosaki, Shigeru Watanabe
Nov 5, 2016·Neurobiology of Learning and Memory·Nathaniel G HarnettDavid C Knight
Jan 26, 2017·Hippocampus·Reilly C HannapelMarise B Parent
Dec 17, 2017·Learning & Memory·Matthew S Matell, Rebecca B Della Valle
Feb 28, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Marise B ParentYoko O Henderson
Aug 23, 2018·Frontiers in Neuroscience·Sorinel A OprisanCatalin V Buhusi
Feb 5, 2021·Science Advances·Akihiro ShimboShigeyoshi Fujisawa
Jan 29, 2021·Journal of Theoretical Biology·Tristan AftCatalin V Buhusi
Nov 21, 2017·Journal of Theoretical Biology·Sorinel A OprisanCatalin V Buhusi

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