Dorsal language stream anomalies in an inherited speech disorder

Brain : a Journal of Neurology
F LiégeoisA T Morgan

Abstract

Speech disorders are highly prevalent in the preschool years, but frequently resolve. The neurobiological basis of the most persistent and severe form, apraxia of speech, remains elusive. Current neuroanatomical models of speech processing in adults propose two parallel streams. The dorsal stream is involved in sound to motor speech transformations, while the ventral stream supports sound/letter to meaning. Data-driven theories on the role of these streams during atypical speech and language development are lacking. Here we provide comprehensive behavioural and neuroimaging data on a large novel family where one parent and 11 children presented with features of childhood apraxia of speech (the same speech disorder associated with FOXP2 variants). The genetic cause of the disorder in this family remains to be identified. Importantly, in this family the speech disorder is not systematically associated with language or literacy impairment. Brain MRI scanning in seven children revealed large grey matter reductions over the left temporoparietal region, but not in the basal ganglia, relative to typically-developing matched peers. In addition, we detected white matter reductions in the arcuate fasciculus (dorsal language stream) bilat...Continue Reading

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Citations

Jun 22, 2019·Clinical Linguistics & Phonetics·Lawrence D ShribergJenny H McGlothlin
Sep 4, 2019·Journal of Speech, Language, and Hearing Research : JSLHR·Susan Rvachew, Tanya Matthews
Dec 10, 2020·European Journal of Human Genetics : EJHG·Amanda BrignellAngela T Morgan
Jul 29, 2021·Journal of Child Neurology·Simona FioriAnna Chilosi
Jul 23, 2019·Folia Phoniatrica Et Logopaedica : Official Organ of the International Association of Logopedics and Phoniatrics (IALP)·Samantha J TurnerAngela T Morgan
Dec 2, 2021·Stroke; a Journal of Cerebral Circulation·Xiaofeng DengJizong Zhao

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