PMID: 6537983Jan 9, 1984Paper

Dorsal noradrenergic bundle lesions fail to alter opiate withdrawal or suppression of opiate withdrawal by clonidine

Life Sciences
K T BrittonG F Koob

Abstract

Previous work has shown that clonidine effectively suppresses many of the signs of opiate withdrawal. The present study was designed to test the hypothesis that the suppression of opiate withdrawal by clonidine is mediated by forebrain noradrenergic projections of the locus coeruleus. Two groups of 24 rats each were subjected to either a 6-hydroxydopamine lesion of the dorsal noradrenergic bundle (Lesion group) or a sham, vehicle injection (Sham group). All rats were made dependent on morphine by subcutaneous implantation of one 75 mg silastic morphine pellet for three days followed by 3 more days with two additional 75 mg pellets. Following removal of the morphine pellet, withdrawal was precipitated in all rats by subcutaneous injection of 4 mg/kg of naloxone. Pretreatment 10 min. before withdrawal with clonidine (0.1 or 0.2 mg/kg) produced a significant attenuation of withdrawal signs as compared to saline injected rats; this effect was equally significant in both sham and lesion groups. Lesions of the locus coeruleus had no effect on withdrawal, nor did they affect the ameliorating action of clonidine. These results substantiate the observation that clonidine can effectively attenuate signs of opiate withdrawal in the rat, b...Continue Reading

References

Mar 1, 1977·Neuropharmacology·B S Sastry, J W Phillis
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Citations

May 1, 1988·Pharmacology, Biochemistry, and Behavior·S J GrantD E Redmond
Jun 1, 1988·Pharmacology, Biochemistry, and Behavior·B Söderpalm, J A Engel
May 1, 1994·Pharmacology, Biochemistry, and Behavior·G A Higgins, E M Sellers
May 1, 1992·Trends in Neurosciences·G F KoobL Stinus
Jan 28, 1991·Neuroscience Letters·S TanganelliL Beani
Apr 1, 1997·Trends in Pharmacological Sciences·M J ChristieC E Bellchambers
Oct 7, 1998·Progress in Neurobiology·N Singewald, A Philippu
Jul 23, 1999·Annals of the New York Academy of Sciences·G Aston-JonesY Zhu
Jul 21, 2015·Neuropharmacology·Erin Cummins JacklinFrancesco Leri
Jan 1, 1987·Acta Psychiatrica Scandinavica. Supplementum·E Eriksson
Mar 19, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Olga ValverdeRafael Maldonado
Jan 12, 2001·Physiological Reviews·J T WilliamsO Manzoni

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