Dorsal premotor activity and connectivity relate to action selection performance after stroke

Human Brain Mapping
Jill Campbell StewartSteven C Cramer

Abstract

Compensatory activation in dorsal premotor cortex (PMd) during movement execution has often been reported after stroke. However, the role of PMd in the planning of skilled movement after stroke has not been well studied. The current study investigated the behavioral and neural response to the addition of action selection (AS) demands, a motor planning process that engages PMd in controls, to movement after stroke. Ten individuals with chronic, left hemisphere stroke and 16 age-matched controls made a joystick movement with the right hand under two conditions. In the AS condition, participants moved right or left based on an abstract, visual rule; in the execution only condition, participants moved in the same direction on every trial. Despite a similar behavioral response to the AS condition (increase in reaction time), brain activation differed between the two groups: the control group showed increased activation in left inferior parietal lobule (IPL) while the stroke group showed increased activation in several right/contralesional regions including right IPL. Variability in behavioral performance between participants was significantly related to variability in brain activation. Individuals post-stroke with relatively poorer ...Continue Reading

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Citations

Aug 1, 2018·Journal of Neural Engineering·S L NormanD J Reinkensmeyer
Jul 7, 2017·Translational Stroke Research·Norihito ShimamuraHiroki Ohkuma
Mar 7, 2019·Frontiers in Neurology·Robert SchulzFriedhelm C Hummel
Mar 30, 2018·Frontiers in Human Neuroscience·Cristian B CalderonWim Gevers
Oct 9, 2020·Neural Plasticity·Jill Campbell StewartStacy L Fritz
May 11, 2021·Journal of Neuroscience Methods·Allison F Lewis, Jill C Stewart
May 17, 2021·Journal of Bodywork and Movement Therapies·Tamise Aguiar CairesGustavo José Luvizutto
Dec 23, 2021·Neurorehabilitation and Neural Repair·Steven C CramerCarolee J Winstein

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