Dorsal premotor cortex: neural correlates of reach target decisions based on a color-location matching rule and conflicting sensory evidence

Journal of Neurophysiology
Émilie CoallierJohn F Kalaska

Abstract

We recorded single-neuron activity in dorsal premotor (PMd) and primary motor cortex (M1) of two monkeys in a reach-target selection task. The monkeys chose between two color-coded potential targets by determining which target's color matched the predominant color of a multicolored checkerboard-like Decision Cue (DC). Different DCs contained differing numbers of colored squares matching each target. The DCs provided evidence about the correct target ranging from unambiguous (one color only) to very ambiguous and conflicting (nearly equal number of squares of each color). Differences in choice behavior (reach response times and success rates as a function of DC ambiguity) of the monkeys suggested that each applied a different strategy for using the target-choice evidence in the DCs. Nevertheless, the appearance of the DCs evoked a transient coactivation of PMd neurons preferring both potential targets in both monkeys. Reach response time depended both on how long it took activity to increase in neurons that preferred the chosen target and on how long it took to suppress the activity of neurons that preferred the rejected target, in both correct-choice and error-choice trials. These results indicate that PMd neurons in this task ...Continue Reading

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Citations

Jun 24, 2015·The Journal of Comparative Neurology·Jon H Kaas, Iwona Stepniewska
Dec 5, 2015·Frontiers in Behavioral Neuroscience·Lalitta Suriya-Arunroj, Alexander Gail
Mar 31, 2015·PLoS Computational Biology·Adrian M HaithJohn W Krakauer
Apr 18, 2020·The European Journal of Neuroscience·Jonathan E RubinTimothy Verstynen
May 21, 2020·ELife·Shreesh P Mysore, Ninad B Kothari
Sep 27, 2018·Scientific Reports·Pierpaolo PaniStefano Ferraina
Sep 22, 2017·Nature Communications·Chandramouli ChandrasekaranKrishna V Shenoy
Aug 10, 2018·Nature Reviews. Neuroscience·Jason P GallivanJ Randall Flanagan
Sep 5, 2018·Nature Communications·Brian M DeklevaLee E Miller
Oct 7, 2019·Journal of Neuroscience Methods·Chandramouli Chandrasekaran, Guy E Hawkins
Sep 7, 2021·ELife·Laith Alhussein, Maurice A Smith

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