Dorsal Striatal Circuits for Habits, Compulsions and Addictions

Frontiers in Systems Neuroscience
David M LiptonAmi Citri

Abstract

Here, we review the neural circuit bases of habits, compulsions, and addictions, behaviors which are all characterized by relatively automatic action performance. We discuss relevant studies, primarily from the rodent literature, and describe how major headway has been made in identifying the brain regions and neural cell types whose activity is modulated during the acquisition and performance of these automated behaviors. The dorsal striatum and cortical inputs to this structure have emerged as key players in the wider basal ganglia circuitry encoding behavioral automaticity, and changes in the activity of different neuronal cell-types in these brain regions have been shown to co-occur with the formation of automatic behaviors. We highlight how disordered functioning of these neural circuits can result in neuropsychiatric disorders, such as obsessive-compulsive disorder (OCD) and drug addiction. Finally, we discuss how the next phase of research in the field may benefit from integration of approaches for access to cells based on their genetic makeup, activity, connectivity and precise anatomical location.

References

Apr 1, 1979·Neuroscience Letters·R M Beckstead
Nov 27, 1999·Science·M S JogA M Graybiel
Mar 14, 2002·Depression and Anxiety·Cheryl N CarminKaren L Gillock
Mar 13, 2003·Cerebral Cortex·Simon Killcross, Etienne Coutureau
Dec 4, 2003·Behavioural Brain Research·Laura H Corbit, Bernard W Balleine
Jan 31, 2004·The European Journal of Neuroscience·Henry H YinBernard W Balleine
Feb 20, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Krista McFarlandPeter W Kalivas
Aug 3, 2004·Learning & Memory·Henry H Yin, Barbara J Knowlton
Aug 18, 2004·Science·Louk J M J Vanderschuren, Barry J Everitt
Jul 28, 2005·The European Journal of Neuroscience·Henry H YinBernard W Balleine
Sep 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Paul S A KalanithiFlora M Vaccarino
Sep 24, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Louk J M J VanderschurenBarry J Everitt
Oct 28, 2005·Nature Neuroscience·Barry J Everitt, Trevor W Robbins
May 23, 2006·Nature Reviews. Neuroscience·Henry H Yin, Barbara J Knowlton
Apr 13, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vivian V ValentinJohn P O'Doherty
Jul 27, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Saïd KourrichMark J Thomas
Aug 31, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ami Citri, Robert C Malenka
Oct 20, 2007·Biological Psychiatry·Dominique GuehlPierre Burbaud
Jun 6, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jamie PetersPeter W Kalivas
Jun 19, 2008·Annual Review of Neuroscience·Ann M Graybiel
Oct 30, 2008·Frontiers in Integrative Neuroscience·Monica R F HilárioRui M Costa
Nov 29, 2008·Neuron·Anatol C Kreitzer, Robert C Malenka
Aug 1, 2009·Science·Eduardo Dias-FerreiraNuno Sousa
Sep 25, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bernard W Balleine, John P O'Doherty
Nov 12, 2010·European Psychiatry : the Journal of the Association of European Psychiatrists·Y SakaiK Fukui
Nov 19, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Agustin ZapataToni S Shippenberg
May 17, 2011·The American Journal of Psychiatry·Claire M GillanSanne de Wit
Dec 27, 2011·Neuron·Lei Phillip WangJoe Z Tsien
Jan 21, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nura W Lingawi, Bernard W Balleine
Mar 13, 2012·Biological Psychology·Lee HogarthMarcus R Munafò
Mar 24, 2012·Biological Psychiatry·Laura H CorbitPatricia H Janak
Mar 30, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sietse JonkmanBarry J Everitt

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Citations

Sep 10, 2020·International Journal of Molecular Sciences·Yosef AvchalumovChitra Mandyam
Jan 23, 2021·Neuropharmacology·R MaldonadoE Martín-García
Feb 1, 2021·Developmental Cognitive Neuroscience·Eun Jung ChoiSoon-Hyung Yi
Mar 5, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Zachary Pierce-Messick, Laura H Corbit
May 22, 2021·Biological Psychiatry·Brandon D Turner
Jul 21, 2021·Biological Psychiatry·Sebastiano Bariselli, David M Lovinger
Aug 8, 2021·International Journal of Molecular Sciences·Yosef AvchalumovChitra D Mandyam
Apr 24, 2020·NeuroImage·Zsolt BedaJoseph Orr

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Methods Mentioned

BETA
RNA-seq

Software Mentioned

smFISH

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