Dorsal turning of motor corticospinal axons at the pyramidal decussation requires plexin signaling.

Neural Development
Regina L FaulknerHwai-Jong Cheng

Abstract

The development of the corticospinal tract (CST) in higher vertebrates relies on a series of axon guidance decisions along its long projection pathway. Several guidance molecules are known to be involved at various decision points to regulate the projection of CST axons. However, previous analyses of the CST guidance defects in mutant mice lacking these molecules have suggested that there are other molecules involved in CST axon guidance that are yet to be identified. In this study, we investigate the role of plexin signaling in the guidance of motor CST axons in vivo. Expression pattern studies show that plexin-A3, plexin-A4, and neuropilin-1 are expressed in the developing cerebral cortex when the motor CST axons originating from layer V cortical neurons are guided down to the spinal cord. By analyzing mutant mice, we show that motor CST axons that turn dorsally to cross the midline at the pyramidal decussation require plexin-A3 and plexin-A4 signaling. Although other CST guidance defects are found in neuropilin-1 mutants, this dorsal turning defect is not observed in either neuropilin-1 or neuropilin-2 mutants, suggesting that the local cues that activate plexin signaling at the dorsal turning point are membrane-bound semaph...Continue Reading

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Citations

Dec 10, 2008·Neural Development·Annette E RünkerKevin J Mitchell
Aug 13, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jae K LeeBinhai Zheng
Apr 3, 2012·Journal of Chemical Neuroanatomy·Claire-Anne GutekunstRobert E Gross
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Jun 28, 2014·Journal of Chemical Neuroanatomy·Claire-Anne Gutekunst, Robert E Gross
Jun 18, 2015·Frontiers in Neuroanatomy·Quentin WelniarzEmmanuel Roze
Sep 18, 2013·Neuroscience·E Leyva-Díaz, G López-Bendito
Jul 9, 2016·PloS One·Francesc Perez-BranguliKevin J Mitchell
Oct 6, 2016·Developmental Neurobiology·Quentin WelniarzEmmanuel Roze
Sep 26, 2012·Blood·Marta SegarraGiovanna Tosato

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