Dorsal-ventral signaling in limb development

Current Opinion in Cell Biology
K D Irvine, T F Vogt

Abstract

In both Drosophila wings and vertebrate limbs, signaling between dorsal and ventral cells establishes an organizer that promotes limb formation. Significant progress has been made recently towards characterizing the signaling interactions that occur at the dorsal-ventral limb border. Studies of chicks have indicated that, as in Drosophila, this signaling process requires the participation of Fringe. Studies of Drosophila have indicated that Fringe functions by inhibiting the ability of Notch to be activated by one ligand, Serrate, while potentiating the ability of Notch to be activated by another ligand, Delta. Recent studies of both Drosophila and vertebrates have also shed new light on the signaling activity of the dorsal-ventral boundary limb organizer, and have highlighted how this organizer is maintained by feedback mechanisms with neighboring cells.

References

Sep 10, 1976·Science·V FrenchS V Bryant
Aug 24, 1973·Nature·D SummerbellL Wolpert
Jul 1, 1974·Developmental Biology·J A MacCabeJ W Saunders
May 1, 1994·Mechanisms of Development·J F de Celis, A García-Bellido
Mar 15, 1994·Genes & Development·P J SwiatekT Gridley
Jan 22, 1993·Science·J P CousoA Martínez-Arias
Jun 28, 1996·Cell·P A Lawrence, G Struhl
Jul 25, 1996·Nature·C A LoomisA L Joyner
Jul 1, 1996·Trends in Genetics : TIG·M J Cohn, C Tickle
Nov 25, 1996·Developmental Biology·C ShawberG Weinmaster
Jan 1, 1996·Annual Review of Cell and Developmental Biology·W J BrookS M Cohen
May 1, 1997·Nature·M J CohnC Tickle
Jun 26, 1997·Nature·V M PaninK D Irvine
Jul 10, 1997·Nature·T Lecuit, S M Cohen
Aug 14, 1997·Nature·N ShubinS Carroll
Aug 1, 1997·Current Opinion in Genetics & Development·L Niswander
Oct 10, 1997·Cell·R L Johnson, C J Tabin

❮ Previous
Next ❯

Citations

Mar 25, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M Z CadinoucheC Tsilfidis
Sep 3, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J F de Celis
May 10, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Andrea Pasini, David G Wilkinson
Feb 17, 2000·Brain Research. Developmental Brain Research·Y IshiiN Osumi
Oct 6, 1999·Current Opinion in Genetics & Development·O Pourquié
Aug 17, 1999·Current Opinion in Genetics & Development·K D Irvine
Jan 27, 2000·Cytokine & Growth Factor Reviews·A Kikuchi
Jan 5, 2005·Nature Reviews. Genetics·Ethan Bier
Oct 23, 2003·Nature Reviews. Molecular Cell Biology·Nicola Haines, Kenneth D Irvine
Mar 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·A Baonza, A Garcia-Bellido
Mar 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ichiro SekiyaDarwin J Prockop
May 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Trudy CorreiaKenneth D Irvine
Nov 15, 2011·The Journal of Biological Chemistry·Xinghua HouPamela Stanley
Jul 10, 1999·Genes & Development·R Diez del CorralJ Modolell
Nov 1, 2001·Annual Review of Cell and Developmental Biology·K D Irvine, C Rauskolb
Jun 8, 2002·Annual Review of Neuroscience·Nicholas Gaiano, Gord Fishell
Jan 15, 2014·PLoS Genetics·Sujin Bao
Dec 20, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Ke YangMichiko Watanabe
Feb 2, 2006·Immunological Reviews·Ioana VisanCynthia J Guidos
Dec 21, 2012·Development, Growth & Differentiation·Joana NevesFernando Giraldez
Aug 29, 2014·Journal of Cellular and Molecular Medicine·Gabriel Rusanescu, Jianren Mao
Aug 2, 2005·Seminars in Cell & Developmental Biology·Robert A Cornell, Judith S Eisen
Sep 1, 2000·Osteoarthritis and Cartilage·A M DeLiseR S Tuan
Aug 10, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Gonzalo Del MonteJosé Luis De La Pompa
Dec 9, 1998·Current Biology : CB·Y J JiangJ Lewis
Jun 8, 1999·Developmental Biology·C Rauskolb, K D Irvine
Aug 13, 2008·Developmental Cell·Dragana RoguljaKenneth D Irvine
Jan 16, 2003·Cell·Tetsuya Okajima, Kenneth D Irvine
Apr 25, 2009·Developmental Biology·Tien T LeNadean L Brown

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.