Dorsal/ventral hippocampus, fornix, and conditioned place preference

Hippocampus
J Ferbinteanu, R J McDonald

Abstract

Conditioned place preference (CPP) is a learning paradigm requiring formation of associations between reward and particular locations. White and McDonald (Behav Brain Res 1993;55:269-281) demonstrated that amygdala (AMG) lesions impair, while fornix (Fx) lesions enhance learning of this task. In the present experiments, we replicated the effects of AMG and Fx lesions, but we also found that complete hippocampal (HPC) lesions interfere with normal performance. Thus, the effects of Fx and HPC lesions on CPP are opposite. This is in contrast with spatial learning in the water maze. Because it has been demonstrated that damage of dorsal HPC interferes to a greater extent with spatial learning than damage of ventral HPC, we also tested animals with either dorsal or ventral HPC disruptions on CPP. Lesions limited to dorsal HPC were followed by impairment on this task. In contrast, lesions limited to ventral HPC resulted in enhanced learning. We argue that Fx and HPC lesions do not have interchangeable effects in all learning paradigms. To explain the complex pattern of results presently obtained, we propose a novel hypothesis regarding behavioral functions of HPC neural circuits. Implications regarding the interaction between memory ...Continue Reading

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Citations

Jul 9, 2002·Hippocampus·Leonard E Jarrard
Oct 3, 2003·Neurobiology of Learning and Memory·Paul E Gold
Aug 7, 2002·European Journal of Pharmacology·Manizheh KaramiHedayat Sahraei
Mar 29, 2001·Behavioural Brain Research·R J McDonaldN S Hong
Jan 30, 2002·Neuroscience Letters·Costas Papatheodoropoulos, George Kostopoulos
Jun 25, 2003·Neuroscience Letters·Janina FerbinteanuRobert J McDonald
Feb 20, 2003·Neurobiology of Learning and Memory·Christa K McIntyrePaul E Gold
Dec 4, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·José A MorónLakshmi A Devi
Mar 27, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Laura E WiseAron H Lichtman
Mar 5, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rutsuko Ito, Melissa Canseliet
May 6, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Scott E KanoskiHarvey J Grill
Jan 26, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Guobin BaoGang Pei
Feb 22, 2005·Genes, Brain, and Behavior·J M BarkerR Boonstra
Nov 13, 2012·PloS One·Jason S SnyderHeather A Cameron
Apr 2, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David J RademacherGloria E Meredith
Jun 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·Stephen M TaubenfeldCristina M Alberini
Dec 7, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Katherine R SherrillChantal E Stern
Jun 24, 2009·Physiology & Behavior·Magdalena Méndez-LópezJorge L Arias
May 31, 2008·Brain Research·Ioannis LiagkourasGeorgios C Papadopoulos
Jan 16, 2007·Neuroscience·N M ConejoJ L Arias
Mar 21, 2007·Pharmacology, Biochemistry, and Behavior·Sarah A Eisenstein, Philip V Holmes
Dec 19, 2006·Pharmacology, Biochemistry, and Behavior·Mohammad SharifzadehAli-Reza Zamanian
Jul 25, 2008·Hippocampus·Jennifer CzerniawskiTim Otto
Nov 1, 2007·The European Journal of Neuroscience·David J RademacherGloria E Meredith

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