PMID: 7547472Jun 1, 1995Paper

Dorso-ventral and rostro-caudal sequential expression of M-twist in the postimplantation murine embryo

Mechanisms of Development
C StoetzelF Perrin-Schmitt

Abstract

M-twist is the murine homolog of the Drosophila twist gene which is a zygotic target for maternal genes that establish embryonic dorso-ventral polarity and is necessary for mesoderm formation. We recently showed that before gastrulation, M-twist transcripts are detected in morulae and blastocysts, then in extra-embryonic tissues of early implanted mouse embryos before the onset of gastrulation, and we suggested that M-twist might be involved in embryonic polarity (Stoetzel et al., submitted). Here, using in situ hybridization on whole mount embryos, we present the expression pattern of M-twist from primitive streak stage up to 10.5 days p.c. In implanted embryos, M-twist is first expressed in extra-embryonic tissues, then in embryo proper around egg cylinder stage within some embryonic ectodermal cells of the primitive streak. Slightly later, scattered cells within the amniotic cavity apparently detached from the primitive streak also express the gene. Then, M-twist transcripts accumulate in head mesenchyme, the first aortic arches, somites and lateral mesoderm and, as development proceeds, successively the second, third and fourth branchial arches, the anterior limb buds and, finally, the posterior limb buds. Thus M-twist expr...Continue Reading

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Citations

Nov 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·E M Füchtbauer
Dec 1, 1996·Mammalian Genome : Official Journal of the International Mammalian Genome Society·P BourgeoisF Perrin-Schmitt
Sep 25, 2002·Biochemical and Biophysical Research Communications·Malika YousfiPierre J Marie
Dec 18, 2007·L' Orthodontie française·William BaconFabienne Perrin-Schmitt
Apr 21, 2009·The International Journal of Developmental Biology·Ralston M Barnes, Anthony B Firulli
Mar 3, 2005·Anatomy and Embryology·Christoph HornikErnst-Martin Füchtbauer
Oct 3, 2002·Evolution & Development·Alexander J NederbragtWim J A G Dictus
Sep 5, 2012·Birth Defects Research. Part A, Clinical and Molecular Teratology·Irene E Zohn, Anjali A Sarkar
Apr 12, 2013·Journal of Tissue Engineering and Regenerative Medicine·Mairéad A ClearyRoberto Narcisi
Sep 18, 1998·Mechanisms of Development·P Francis-WestA Graveson
Jun 24, 2004·Mechanisms of Development·Junichi YasutakeAkira Kudo
Dec 15, 2010·Translational Oncology·Natacha Entz-WerléFabienne Perrin-Schmitt
Aug 7, 2004·Mechanisms of Development·C-Y Kelly KuanRoger J Keynes
Jun 10, 2008·Developmental Biology·Joshua W VincentzAnthony B Firulli
Jul 27, 2002·Developmental Biology·Meredith P O'RourkePatrick P L Tam
May 29, 2013·The Journal of Cell Biology·Elias H BarrigaRoberto Mayor
Dec 31, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·James A WestonShinichi Nishikawa
Jan 1, 1997·Nature Genetics·M J Dixon
Jan 1, 1997·Nature Genetics·V el GhouzziJ Bonaventure
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Jun 5, 1998·The Journal of Biological Chemistry·S YangK Kao
Jan 29, 2019·Frontiers in Genetics·Libo JinJin-San Zhang
Nov 5, 2014·Cancer Research·Keun-Woo LeeSeok-Hyung Kim

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