Dorsomedial hypothalamus mediates autonomic, neuroendocrine, and locomotor responses evoked from the medial preoptic area.

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Joseph L HuntJ A DiMicco

Abstract

Previous studies suggest that sympathetic responses evoked from the preoptic area in anesthetized rats require activation of neurons in the dorsomedial hypothalamus. Disinhibition of neurons in the dorsomedial hypothalamus in conscious rats produces physiological and behavioral changes resembling those evoked by microinjection of muscimol, a GABA(A) receptor agonist and neuronal inhibitor, into the medial preoptic area. We tested the hypothesis that all of these effects evoked from the medial preoptic area are mediated through neurons in the dorsomedial hypothalamus by assessing the effect of bilateral microinjection of muscimol into the DMH on these changes. After injection of vehicle into the dorsomedial hypothalamus, injection of muscimol into the medial preoptic area elicited marked increases in heart rate, arterial pressure, body temperature, plasma ACTH, and locomotor activity and also increased c-Fos expression in the hypothalamic paraventricular nucleus, a region known to control the release of ACTH from the adenohypophysis. Prior bilateral microinjection of muscimol into the dorsomedial hypothalamus produced a modest depression of baseline heart rate and body temperature but completely abolished all changes evoked from...Continue Reading

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Citations

Dec 14, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eugene L DimitrovTed B Usdin
Feb 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yan ZhangHeike Münzberg
Feb 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andras GaramiAndrej A Romanovsky
Feb 11, 2014·Autonomic Neuroscience : Basic & Clinical·Lilia S Urzedo-RodriguesJosmara B Fregoneze
Feb 9, 2013·Endocrinology and Metabolism Clinics of North America·Joerg Heeren, Heike Münzberg
Sep 9, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kazuhiro Nakamura
Feb 7, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yaroslav I MolkovDmitry V Zaretsky
Mar 13, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Evgeny BondarenkoEugene Nalivaiko
Oct 1, 2014·Temperature : Multidisciplinary Biomedical Journal·Yaroslav I Molkov, Dmitry V Zaretsky
Feb 15, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Carlos Henrique XavierEugene Nalivaiko
Mar 31, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R PanditR A H Adan
Dec 16, 2020·ELife·Jennifer D DeemGregory J Morton
May 27, 2021·Cell Metabolism·Ramón A PiñolMarc L Reitman

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