Dorsoventral lineage restriction in wing imaginal discs requires Notch

C A Micchelli, S S Blair


The formation of boundaries that prevent the intermixing of cells is an important developmental patterning mechanism. The compartmental lineage restrictions that appear in the developing imaginal discs of Drosophila are striking examples of such boundaries. However, little is known about the cellular mechanism underlying compartmental lineage restrictions. The dorsoventral (D/V) lineage restriction that arises late in the developing wing imaginal disc requires the dorsal expression of the transcription factor Apterous and it has been hypothesized that apterous (ap) maintains compartmentalization by directly regulating the expression of molecules that modify cell adhesion or affinity. However, ap expression also regulates signalling between dorsal and ventral compartments, resulting in high levels of Notch signalling at the D/V boundary. Here we show that the formation of Notch-dependent boundary cells is required for the D/V lineage restriction.


May 10, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Andrea Pasini, David G Wilkinson
Jan 6, 2006·Molecular Genetics and Genomics : MGG·Takashi J FuwaKenji Matsuno
Oct 14, 2000·Annual Review of Cell and Developmental Biology·R S Mann, G Morata
Nov 1, 2001·Annual Review of Cell and Developmental Biology·Kenneth D Irvine, C Rauskolb
Jun 26, 2009·Development·Nikolas NikolaouDavid G Wilkinson
Nov 8, 2012·Development·Giovanna M ColluKeith Brennan
Dec 20, 2012·Development·Emily Marcinkevicius, Jennifer A Zallen
Feb 15, 2012·Journal of Cell Science·Elena Domanitskaya, Trudi Schüpbach
Oct 8, 2011·PLoS Computational Biology·Oriol Canela-XandriJavier Buceta
Jun 20, 2014·Cellular and Molecular Life Sciences : CMLS·Giovanna M ColluKeith Brennan
Mar 26, 2011·Cellular and Molecular Life Sciences : CMLS·Bruno MonierBénédicte Sanson
Dec 18, 2010·Nature Reviews. Genetics·Christian DahmannMichael Brand
Dec 9, 2014·Cell Adhesion & Migration·David G Wilkinson
Jul 1, 2016·Fly·Marcus Michel, Christian Dahmann
Sep 27, 2005·Developmental Biology·Yun FanHeinrich Reichert
Oct 19, 2017·Development·Natalie A DyeSuzanne Eaton
Jun 29, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Shyam M ManisastryKersti K Linask
Mar 17, 2001·Nature Reviews. Molecular Cell Biology·G Morata
Jan 26, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Héctor Herranz, M Milán
Feb 8, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·George StratigopoulosRudolph L Leibel
May 25, 2010·Fly·Daiki Umetsu, Christian Dahmann
Nov 5, 2016·Annual Review of Entomology·Xavier Belles
Mar 11, 2015·Wiley Interdisciplinary Reviews. Developmental Biology·Daiki Umetsu, Christian Dahmann
Jul 28, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Florence Janody, Jessica E Treisman
Oct 3, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Robert J Major, Kenneth D Irvine


Mar 1, 1985·Developmental Biology·D L BrowerL A Reger
May 1, 1994·Mechanisms of Development·J F de Celis, A García-Bellido
Jun 26, 1997·Nature·V M PaninKenneth D Irvine
Oct 23, 1997·Nature·I Rodriguez, K Basler
Feb 28, 1998·Current Biology : CB·S S Blair
Apr 30, 1999·Science·S Artavanis-TsakonasR J Lake

Related Concepts

Ap protein, Drosophila
Receptors, Notch
Suppressor of Hairless protein, Drosophila
Notch protein, Drosophila
Drosophila melanogaster Proteins
Recombination, Genetic
Repressor Molecules
Homeodomain Proteins
LIM-Homeodomain Proteins

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.