Dorzolamide-induced immune thrombocytopenia: a case report and literature review

Journal of Glaucoma
X D Martin, M Danese

Abstract

To report a severe case of dorzolamide-induced immune thrombocytopenia, to review the literature on this topic, and to draw attention to the serious potential side effects of this topical sulfonamide. An 83-year-old man with primary open-angle glaucoma in both eyes who was taking topical dorzolamide therapy for 3.5 years developed a severe thrombocytopenia (10,000 platelets/microL). The amount of platelets was not influenced by prednisone therapy but increased rapidly to 100,000/microL after the withdrawal of dorzolamide. Although the potential capacity of sulfonamides to induce thrombocytopenia is well known, no case of dorzolamide-induced immune thrombocytopenia was published in the medical literature until July 2000. Considering the possible severe side effects that can be induced by topical dorzolamide 2%, ophthalmologists should carefully evaluate during the medical history of their patients the risk of sensitivity to sulfonamides.

References

Apr 1, 1978·American Journal of Ophthalmology·P R LichterO V Beall
Apr 28, 1999·American Journal of Ophthalmology·A KonowalR J Epstein
Aug 17, 1999·Archives of Ophthalmology·J CarlsenA Crandall
Oct 8, 1999·American Journal of Ophthalmology·C J Ingram, R F Brubaker
Dec 28, 1999·American Journal of Ophthalmology·I Adamsons
Feb 9, 2000·Survey of Ophthalmology·L DeSantis

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Citations

Oct 1, 2014·Expert Opinion on Pharmacotherapy·Sky K ChewIvan Goldberg
Mar 13, 2014·Expert Opinion on Drug Safety·Erik R Swenson
Dec 8, 2015·Journal of the American Veterinary Medical Association·Billie Beckwith-CohenRichard R Dubielzig
Apr 3, 2003·Journal of Glaucoma·William C StewartJessica N Leech
Jan 16, 2018·British Journal of Clinical Pharmacology·Iva Hoffmanová, Daniel Sánchez

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