Dosage compensation in mammals

Cold Spring Harbor Perspectives in Biology
Neil Brockdorff, Bryan M Turner

Abstract

Many organisms show major chromosomal differences between sexes. In mammals, females have two copies of a large, gene-rich chromosome, the X, whereas males have one X and a small, gene-poor Y. The imbalance in expression of several hundred genes is lethal if not dealt with by dosage compensation. The male-female difference is addressed by silencing of genes on one female X early in development. However, both males and females now have only one active X chromosome. This is compensated by twofold up-regulation of genes on the active X. This complex system continues to provide important insights into mechanisms of epigenetic regulation.

Citations

Mar 17, 2016·Progress in Biophysics and Molecular Biology·John S Torday, William B Miller
Apr 27, 2016·Seminars in Cell & Developmental Biology·Bernhard Payer
May 31, 2016·Clinical Epigenetics·Koraljka Gall TrošeljDjurdjica Ugarkovic
Jan 31, 2017·Nature Structural & Molecular Biology·Maud BorenszteinEdith Heard
Mar 21, 2017·ELife·Ziwei LiangMatthias Merkenschlager
Mar 20, 2019·The Journal of Neuropsychiatry and Clinical Neurosciences·Andrea AccogliYannis Trakadis
May 30, 2019·Cellular and Molecular Life Sciences : CMLS·Huiying ZouHuabin Zhu
Aug 25, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Néstor Saiz, Anna-Katerina Hadjantonakis
Jul 3, 2016·Cold Spring Harbor Perspectives in Biology·Stavros Lomvardas, Tom Maniatis
Aug 4, 2018·Analytical Cellular Pathology (Amsterdam)·Anubhav Chakraborty, Pragasam Viswanathan
Aug 21, 2020·Genetics, Selection, Evolution : GSE·Tom Druet, Andres Legarra
Jun 24, 2017·Epigenetics & Chromatin·Gautier RichardGaël Le Trionnaire
Jan 1, 2015·AIMS Biophysics·Qiao Yi ChenHong Sun
Apr 18, 2020·Current Opinion in Genetics & Development·Jennifer M Luppino, Eric F Joyce
Feb 20, 2021·Molecular Ecology·Michail Rovatsos, Lukáš Kratochvíl
Jul 13, 2021·Frontiers in Cell and Developmental Biology·Yaping JiangYihui Chen
Jun 2, 2021·Molecular and Cellular Biology·Rini ShahSanjeev Galande
Jul 27, 2021·Trends in Genetics : TIG·Maximilian W D RaasHendrik Marks
Jul 27, 2021·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michail RovatsosLukáš Kratochvíl
Sep 15, 2021·Molecular Biology and Evolution·Kevin R BredemeyerWilliam J Murphy
Jul 28, 2021·Annual Review of Genetics·Gabrielius Jakutis, Didier Y R Stainier

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cellular and Molecular Life Sciences : CMLS
Eugénie PessiaGabriel A B Marais
Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology
Katie E ProtheroLaura Carrel
Reproduction : the Official Journal of the Society for the Study of Fertility
Takashi Sado, Takehisa Sakaguchi
© 2022 Meta ULC. All rights reserved