Dosage-dependent effects of permethrin-treated nets on the behaviour of Anopheles gambiae and the selection of pyrethroid resistance

Malaria Journal
Vincent CorbelP Guillet

Abstract

The evolution and spread of pyrethroid resistance in Anopheles gambiae s.s, the major malaria vector in sub-Saharan Africa, is of great concern owing to the importance of pyrethroid-treated nets in the WHO global strategy for malaria control. The impact of kdr (the main pyrethroid-resistance mechanism) on the behaviour of An. gambiae is not well understood. The objective of this study was to determine whether high or low doses of permethrin differ in their resistance-selection effects. The effect of permethrin treatment was assessed under laboratory conditions using the tunnel test technique against susceptible, heterozygous and homozygous genotypes. Experimental huts trials were then carried out in Benin to assess the level of personal protection conferred by nets treated with a variety of permethrin concentrations and their impact on the selection for kdr allele. Tunnel tests showed that nets treated with permethrin at 250 and 500 mg/m2 induced higher mortality and blood feeding reduction among susceptible and heterozygous (RS) females as compared to the lower concentration (100 mg/m2). The experimental hut trials showed that the best personal protection was achieved with the highest permethrin concentration (1,000 mg/m2). Mo...Continue Reading

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Citations

Aug 9, 2008·Malaria Journal·Eliningaya J KwekaEmmanuel A Temu
Mar 26, 2010·Malaria Journal·Anges W YadouletonMartin C Akogbeto
Nov 4, 2008·Emerging Infectious Diseases·Cédric PennetierJean-Marc Hougard
Jun 6, 2009·Journal of Medical Entomology·Stephane DuchonVincent Corbel
Sep 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Rob AndriessenMarit Farenhorst
Apr 28, 2006·Tropical Medicine & International Health : TM & IH·A DiabateJ-M Hougard
Apr 7, 2015·Journal of the American Mosquito Control Association·Steven DenhamKarla Saavedra-Rodriguez
Mar 7, 2009·Journal of Vector Ecology : Journal of the Society for Vector Ecology·Kofi Adasi, Janet Hemingway
Feb 21, 2009·Tropical Medicine & International Health : TM & IH·Raphael N'GuessanMark Rowland
Dec 18, 2007·Transactions of the Royal Society of Tropical Medicine and Hygiene·Raphael N'guessanMark Rowland
Mar 15, 2011·Medical and Veterinary Entomology·J D BohbotJ C Dickens
May 25, 2020·Journal of Mathematical Biology·Iboi EnahoroKrijn Paaijmans
Mar 15, 2019·Parasites & Vectors·Emilie DeletreFabrice Chandre

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Methods Mentioned

BETA
PCR
genotyping

Software Mentioned

Statistica
Stat )
Genopop R

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