Dosage-Dependent Impact of Acute Serotonin Enhancement on Transcranial Direct Current Stimulation Effects.

The International Journal of Neuropsychopharmacology
Lorena MeloMin-Fang Kuo

Abstract

The serotonergic system has an important impact on basic physiological and higher brain functions. Acute and chronic enhancement of serotonin levels via selective serotonin reuptake inhibitor administration impacts neuroplasticity in humans, as shown by its effects on cortical excitability alterations induced by non-invasive brain stimulation, including transcranial direct current stimulation (tDCS). Nevertheless, the interaction between serotonin activation and neuroplasticity is not fully understood, particularly considering dose-dependent effects. Our goal was to explore dosage-dependent effects of acute serotonin enhancement on stimulation-induced plasticity in healthy individuals. Twelve healthy adults participated in 7 sessions conducted in a crossover, partially double-blinded, randomized, and sham-controlled study design. Anodal and cathodal tDCS was applied to the motor cortex under selective serotonin reuptake inhibitor (20 mg/40 mg citalopram) or placebo medication. Motor cortex excitability was monitored by single-pulse transcranial magnetic stimulation. Under placebo medication, anodal tDCS enhanced, and cathodal tDCS reduced, excitability for approximately 60-120 minutes after the intervention. Citalopram enhanced...Continue Reading

References

Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M M PanickerR Miledi
Jul 18, 1997·Brain Research. Developmental Brain Research·L KojicM S Cynader
Aug 5, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J J Mann
Aug 26, 1999·Neuropharmacology·N M Barnes, T Sharp
Dec 22, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·I LoubinouxF Chollet
Dec 18, 2003·Supplements to Clinical Neurophysiology·Michael A NitscheWalter Paulus
Jun 5, 2004·Journal of the Neurological Sciences·Elisa RobolPaolo Manganotti
Jun 17, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael A NitscheWalter Paulus
Sep 29, 2004·Neuron·Robert C Malenka, Mark F Bear
Jan 24, 2007·Biological Psychiatry·Claus NormannMichael Bach
Mar 23, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yan-You Huang, Eric R Kandel
Jan 31, 2008·Journal of Speech, Language, and Hearing Research : JSLHR·Jeffrey A Kleim, Theresa A Jones
Apr 9, 2008·Behavioural Brain Research·Sven Ove OgrenOliver Stiedl
Apr 9, 2008·Behavioural Brain Research·B BertH Bönisch
Apr 24, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Charlotte J StaggHeidi Johansen-Berg
May 12, 2009·Biological Psychiatry·Michael A NitscheWalter Paulus
Nov 17, 2009·Biochemical Society Transactions·C Geoffrey LauR Suzanne Zukin
Jul 1, 2008·Brain Stimulation·Michael A NitscheAlvaro Pascual-Leone
Feb 16, 2011·The International Journal of Neuropsychopharmacology·Andre Russowsky BrunoniFelipe Fregni
Mar 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kathleen ScullionG Campbell Teskey
May 18, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Giorgi BatsikadzeMichael A Nitsche
Jun 20, 2013·Experimental Brain Research·Gergely OrbanGiuseppe Di Giovanni
Feb 14, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shane FresnozaMin-Fang Kuo
Mar 19, 2014·Brain Stimulation·Sarah WiethoffJohn C Rothwell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Colleen A DockeryChristian Plewnia
© 2021 Meta ULC. All rights reserved