Dosage Form Developments of Nanosuspension Drug Delivery System for Oral Administration Route

Current Pharmaceutical Design
Ang ChenHuiming Hou

Abstract

A large amount of new drug candidates are practically insoluble in aqueous solvents and are even simultaneously poorly soluble in organic solvents. Nanosuspension drug delivery system (DDS) was firstly developed in 1994 and has attracted more and more attention as a formation solution for the poorly soluble drugs. By nansizing the poorly soluble drugs, nanosuspensions have several outstanding advantages for drug delivery. Among many administration routes of drug delivery, oral administration is the most preferred route due to its advantages such as ease of ingestion, versatility to accommodate various types of drug candidates, low production cost, high safety, good patient compliance, and pain avoidance. Current marketed pharmaceutical nanosuspension DDS products are mostly for oral administration. This review is to systematically summarize the nanosuspension DDS dosage form developments of poorly soluble drugs for oral administration use.

Citations

Jan 21, 2019·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Ali Ahmadi TehraniVahid Ramezani
Nov 21, 2019·Drug Delivery·Yuzhu SunShuyu Xie
Dec 10, 2020·International Journal of Nanomedicine·Ze-Liang WuRong Xu
Sep 21, 2017·Molecular Pharmaceutics·Yingyue ZhangRobert K Prud'homme
May 30, 2020·Molecular Pharmaceutics·Alejandro Ruiz-PicazoMarival Bermejo

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