PMID: 8590239Nov 15, 1995Paper

Dosage of gadoteridol and adverse reactions relative to gadopentetate

American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
D E HieronimD P Swanson

Abstract

Compliance with an institution's dosage guidelines for gadoteridol was determined, and adverse reactions to gadoteridol and gadopentetate were compared. Departmental policy in March 1993 set the standard dose of gadoteridol at 0.1 mmol/kg. A dose of 0.05 mmol/kg was set for patients with suspected acoustic neurinomas or pituitary microadenomas. Guidelines allowing a high dose of 0.2 or 0.3 mmol/kg were also established for specific indications involving suspected metastatic disease or inadequate contrast enhancement at the standard dose. Data on gadoteridol use were collected concurrently from May 1993 to January 1994 and included the dose, the indication for the dose, and any adverse reactions. Safety data for patients who had received gadopentetate between June 1988 and March 1990 were also collected and reviewed. The subjects in this retrospective analysis represented the same broad population as those involved in the concurrent evaluation of gadoteridol use. The frequency and types of adverse events in the two groups were compared. During the gadoteridol-review period, 8377 patients underwent magnetic resonance imaging studies; 3558 (42.5%) of them received gadoteridol. Of the 3558 doses given, 3375 (94.9%) were 0.1 mmol/kg...Continue Reading

Citations

Oct 3, 1999·Journal of Magnetic Resonance Imaging : JMRI·V M Runge, M V Knopp
Sep 23, 2008·AJR. American Journal of Roentgenology·Patrick M Colletti
Oct 3, 1999·Journal of Magnetic Resonance Imaging : JMRI·F G Shellock, E Kanal

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