PMID: 375668May 1, 1979Paper

Dosage of salicylates for children with juvenile rheumatoid arthritis. A prospective clinical trial with three different preparations of acetylsalicylic acid

Acta paediatrica Scandinavica
A L MäkelaM Mattila

Abstract

41 children with juvenile rheumatoid arthritis (JRA) and 6 with postinfectious arthropathies, aged 3--15 years, were treated with acetylsalicylic acid for 14 days during which time the patients were hospitalized. Three different acetylsalicylic acid preparations were used: a microencapsulated form, an enteric-coated form and standard acetylsalicylic acid tablets. Serum salicylate concentrations were measured by Trinder's photometric method. With doses of 90--120 mg/kg/day symptoms of salicylism appeared in about 50% of the cases. Daily doses of 2 g/m2 (not exceeding 70 mg/kg) proved relatively safe in this study, whereas symptoms and signs of intoxication appeared at doses exceeding 3 g/m2/day. In this respect there were no significant differences between the three acetylsalicylic acid preparations used. The results of this study also suggest that the serum salicylate concentrations should not exceed 2000 mumol/l (about 27 mg/100 ml). The symptoms of salicylism correlated closely with serum salicylate levels, which, in turn, correlated well with the dosage in g/m2. Elevation of serum aspartate aminotransferase was noted in 1/3 of the cases. All of these had a dose exceeding 2 g/m2, and the frequency of elevated enzyme activitie...Continue Reading

References

Aug 14, 1975·The New England Journal of Medicine·G LevyL K Garrettson
Jan 1, 1977·Scandinavian Journal of Rheumatology·A L Mäkelä
Mar 1, 1978·Clinical Pharmacology and Therapeutics·G Levy, K M Giacomini
Nov 1, 1975·Acta paediatrica Scandinavica·M SillanpääA Koivikko
Jan 1, 1975·Scandinavian Journal of Rheumatology·A L MäkeläJ Haapasaari
Jan 1, 1974·Annals of Internal Medicine·J D WolfeR C Goldstein
Aug 31, 1972·The New England Journal of Medicine·G Levy, T Tsuchiya
Jul 5, 1971·JAMA : the Journal of the American Medical Association·G Levy, J R Leonards
Jul 1, 1965·Journal of Pharmaceutical Sciences·G Levy
Jun 1, 1954·The Biochemical Journal·P TRINDER

❮ Previous
Next ❯

Citations

Jun 1, 1985·Clinical Rheumatology·J P Famaey
Dec 2, 2009·Inflammopharmacology·K D Rainsford
Feb 1, 1980·Archives of Disease in Childhood·G W Rylance, T A Moreland
Oct 1, 1980·British Journal of Clinical Pharmacology·G Levy
Jun 1, 1988·Journal of Clinical Pharmacology·R M Silver
Jun 14, 1983·The American Journal of Medicine·J Baum
Jan 1, 1987·Critical Reviews in Clinical Laboratory Sciences·T C Kwong
Mar 1, 1980·Acta Neurologica Scandinavica·A L MäkeläP Korpela
Oct 1, 1981·Arthritis and Rheumatism·H L Gewanter, J Baum
Jun 1, 1983·Annals of Tropical Paediatrics·J A HamdanA R Sa'di

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.