Dose- and photoperiod-dependent effects of 17beta-estradiol and the anti-estrogen ICI 182,780 on testicular structure, acceleration of spermatogenesis, and aromatase immunoexpression in immature bank voles

Acta histochemica
Monika GancarczykB Bilińska

Abstract

It has been known that administration of estrogens or deficiency of estrogens can affect development and/or maintenance of male gonadal functions. These hormones are able to control germ cell development, and especially spermatid production and epididymis sperm maturation. The aim of the present study was to show the effects of 17beta-estradiol and a pure anti-estrogen, ICI 182,780, on the bank vole testis. Immature bank voles reared under either short or long light cycles were injected intraperitoneally with two doses of either 17beta-estradiol (0.1 and 10 microg/g body weight, respectively) or pure anti-estrogen ICI 182,780 (10 and 100 microg/g body weight, respectively) both dissolved in 20 microl sesame oil. Control groups (from both photoperiods) received 20 microl sesame oil only. The injections were performed twice a week during 2 weeks. Exposure to the low dose of estradiol induced acceleration of the onset of spermatogenesis. This was particularly apparent in voles kept under short light cycle conditions. On the other hand, when males were treated with a high dose of estradiol or ICI 182,780, disruption of testicular structure and tubular atrophy were observed. Increased apoptosis of germ cells was evident. It is concl...Continue Reading

References

Nov 1, 1980·Biology of Reproduction·A O BrinkmannH J Van der Molen
Jun 1, 1995·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J AlmadhidiJ L Gaillard
Jan 1, 1997·Reproduction, Fertility, and Development·B BilińskaB Schmalz
Mar 9, 1999·European Journal of Endocrinology·M Faustini-FustiniC Carani
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·K M RobertsonE R Simpson
Aug 12, 1999·International Journal of Andrology·S CarreauJ Levallet
Oct 21, 1999·Biochemical and Biophysical Research Communications·T MiuraK Yamauchi
Jun 8, 2000·The Journal of Clinical Endocrinology and Metabolism·V PentikäinenL Dunkel
Jun 16, 2001·Endocrine Reviews·L O'DonnellE R Simpson
Aug 22, 2001·Biology of Reproduction·C A OliveiraR A Hess
Feb 28, 2003·Molecular Human Reproduction·Sophie LambardSerge Carreau

❮ Previous
Next ❯

Citations

Apr 21, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Serge Carreau, Rex A Hess
Jan 14, 2010·Folia Histochemica Et Cytobiologica·Eliza FilipiakJolanta Slowikowska-Hilczer
Apr 5, 2014·General and Comparative Endocrinology·Malgorzata Kotula-BalakBarbara Bilinska
Dec 6, 2011·Reproductive Biology·Serge CarreauChristelle Delalande
Mar 19, 2011·General and Comparative Endocrinology·Shilpa BhartiUmesh Rai
Jan 13, 2006·Molecular and Cellular Endocrinology·Serge CarreauSophie Lambard
Feb 10, 2012·Spermatogenesis·Serge CarreauChristelle Delalande
Aug 11, 2015·Expert Reviews in Molecular Medicine·Sara CorreiaSílvia Socorro
Sep 22, 2016·Reproduction in Domestic Animals = Zuchthygiene·S SaraswatA K Goel
Jul 16, 2005·The Journal of Steroid Biochemistry and Molecular Biology·S LambardS Carreau
Feb 24, 2017·Biochemical and Biophysical Research Communications·Rachna Verma, Amitabh Krishna
Nov 27, 2008·Reproduction in Domestic Animals = Zuchthygiene·I KoperaB Bilińska
Mar 6, 2009·Microscopy Research and Technique·Serge CarreauIsabelle Galeraud-Denis
Sep 24, 2020·International Journal of Molecular Sciences·Magdalena Profaska-SzymikRyszard Tuz
May 28, 2020·International Journal of Molecular Sciences·Michal DulibanBarbara Bilinska
May 4, 2011·International Journal of Andrology·R Walczak-JedrzejowskaJ Slowikowska-Hilczer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis