Dose- and sex-dependent alterations in mercury distribution in fetal mice following methylmercury exposure

Journal of Toxicology and Environmental Health
M InouyeK Hirayama

Abstract

Methylmercuric chloride was orally given to inbred C57BL/6N mice on d 13 of pregnancy at doses of 2.5, 5, 10, and 20 mg/kg. Animals were sacrificed on each of d 14-18 of pregnancy, and mercury levels in the brain, liver, and kidney of both the fetus and dam were determined. The dose effect on the time course of mercury accumulation in the brain was observed both in the fetus and dam; after the higher doses administered, the brain mercury reached the highest concentration later than it did after the lower doses. In addition, the mercury concentration in the fetal brain was disproportionately higher after a dose of 20 mg/kg, which was toxic in the fetus since the weight of the brain was reduced. The concentration in the fetal brain was 1.6-4.9 times higher than in the maternal brain. The sex difference of fetuses in mercury levels was observed in the brain after a dose of 2.5 mg/kg, in which mercury concentration was higher in females than in males. This corresponded to the previously reported difference in adult mice and rats. However, the sex difference was not seen after doses of 5, 10, or 20 mg/kg.

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Citations

Mar 6, 2002·Teratology·Michael F O'HaraThomas B Knudsen
Jan 1, 1990·Acta Neuropathologica·J A GeelenA Verhoef
Aug 1, 1988·Archives of Toxicology·M Inouye, Y Kajiwara
Jan 1, 1988·Archives of Toxicology·M Inouye, Y Kajiwara
Jul 1, 1990·Journal of Toxicology and Environmental Health·J B Nielsen, O Andersen
Sep 1, 1992·Journal of Toxicology and Environmental Health·J B Nielsen
Apr 1, 1996·Environmental Health Perspectives·C Watanabe, H Satoh
Mar 27, 2007·Neurotoxicology·E CernichiariT Clarkson
Apr 24, 2012·Medical Hypotheses·Federico A Silva SiegerRonald G García
May 7, 2010·Therapeutic Drug Monitoring·Katherine SchoemanGideon Koren
Mar 13, 2009·Critical Reviews in Toxicology·Shirlee W TanKathryn R Mahaffey

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