Dose- and time-dependent effects of an immune challenge on fish across biological levels.

Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
Quentin PetitjeanSéverine Jean

Abstract

Due to global changes, fish are increasingly exposed to immune challenges associated with disease outbreaks in aquatic ecosystems. Adjustments in physiology and behavior are generally critical to maintaining homeostasis after an immune challenge, but there is limited knowledge on the specific thresholds and dynamics of responses across levels of biological organization in fish. In this study, we tested how different concentrations of an antigens mixture (phytohemagglutinin and lipopolysaccharide) affected innate immunity with potential consequences on oxidative stress, energy reserves, body condition, and behavior across time, using the common gudgeon (Gobio sp.) as model species. The immune challenge induced a transitory increase in lytic enzyme activity (i.e., lysozyme) and local immune response (i.e., skin swelling) 2 days after the antigen injection. The available energy stored in muscle was also reduced 4 days after injection, without inducing oxidative stress at the cellular level. Overall, the immune challenge induced limited costs at the molecular and cellular levels but had strong effects at the whole organism level, especially on behavior. Indeed, fish swimming activity and sociability were affected in a dose- and tim...Continue Reading

References

Jun 1, 1992·Proceedings of the Society for Experimental Biology and Medicine·C Grunfeld, K R Feingold
Jan 22, 1998·Veterinary Immunology and Immunopathology·M J Quade, J A Roth
Nov 23, 2000·Nature·T Finkel, N J Holbrook
Oct 17, 2001·Developmental and Comparative Immunology·A E Ellis
Jan 29, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Hartmut JaeschkeJohn J Lemasters
Feb 12, 2002·International Journal for Parasitology·Kurt Buchmann, T Lindenstrøm
Jun 20, 2002·Veterinary Immunology and Immunopathology·R W Johnson
Apr 22, 2003·The American Naturalist·Camille BonneaudGabriele Sorci
Apr 22, 2003·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Alejandro RodríguezJosé Meseguer
Nov 25, 2003·Cell Stress & Chaperones·Olivier Preynat-SeauveChristian Villiers
Jun 14, 2005·Fish & Shellfish Immunology·Bergljót Magnadóttir
Dec 13, 2005·Biological Reviews of the Cambridge Philosophical Society·David DudgeonCaroline A Sullivan
Dec 14, 2005·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·David CostantiniGiacomo Dell'Omo
Jul 4, 2006·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Katherine A JohansenKen Overturf
Jul 29, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·David Costantini, Giacomo Dell'Omo
Mar 6, 2007·Trends in Immunology·Maciej M MarkiewskiJohn D Lambris
May 15, 2007·Advances in Parasitology·T A BakkeP D Harris
Jul 25, 2007·Parasitology Research·Geraldine LootSovan Lek
Feb 22, 2008·Fish & Shellfish Immunology·S K NayakN K Maiti
May 13, 2008·Journal of Biomedical Materials Research. Part a·Fredrik BexbornKristina Nilsson Ekdahl
Jul 8, 2008·Fish & Shellfish Immunology·P SwainS Dash
Sep 30, 2008·PloS One·José L TellaGuillermo Blanco
Mar 14, 2009·Hormones and Behavior·Rebecca M Calisi, George E Bentley
Mar 24, 2009·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·David Costantini, Anders Pape Møller
Aug 1, 1996·Trends in Ecology & Evolution·B C Sheldon, S Verhulst
Jan 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ashley J W WardJens Krause
Apr 29, 2011·The Journal of Experimental Biology·Katherine A HerbornKathryn E Arnold
Sep 1, 2009·Integrative and Comparative Biology·James S Adelman, Lynn B Martin
Jul 31, 2012·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Mia O HoogenboomDavid Costantini
Mar 1, 1991·Fish Physiology and Biochemistry·M P Pearson, E D Stevens
Jul 6, 2014·Environmental Science and Pollution Research International·S JollyS Betoulle
Aug 20, 2014·Die Naturwissenschaften·Constance M O'ConnorSigal Balshine
Dec 10, 2014·Trends in Parasitology·Robert D AdlardNico J Smit
Jan 6, 2015·Antioxidants & Redox Signaling·Anne D Cherry, Claude A Piantadosi

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