Dose-confirmation studies of the cestocidal activity of pyrantel pamoate paste in horses

Veterinary Parasitology
Craig R ReinemeyerJack I Shugart

Abstract

Dose confirmation studies of the cestocidal activity of pyrantel pamoate paste were conducted at two sites in North America during 2001. Horses with naturally-acquired cestode infections were identified by detection of typical Anoplocephala spp. eggs in feces collected between 7 and 92 days prior to treatment. Twenty and 22 horses were enrolled at Site 1 (Urbana, IL) and Site 2 (Knoxville, TN), respectively. Candidate horses were acclimated to study conditions for 14 days, ranked by length of interval since coprologic confirmation, and allocated randomly to one of two treatment groups: (T1) pyrantel pamoate paste 13.2mg pyrantel base per kilogram body weight administered orally, and (T2) untreated controls. Individual doses of pyrantel pamoate paste were prepared on the basis of contemporaneous body weights and administered to Group T1 horses on Day 0. Trained personnel monitored the animals at regular intervals after treatment to detect potential adverse reactions. Horses were euthanatized and necropsied 10-12 days after treatment. The contents of the large and small intestines were collected, and the walls of each organ were rinsed with water and inspected. Attached cestodes were recovered and preserved in 10% formalin. The i...Continue Reading

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Citations

Mar 24, 2010·Veterinary Parasitology·Craig R ReinemeyerAlan A Marchiondo
Aug 28, 2007·The Veterinary Journal·Steven R KoppGlen T Coleman
May 25, 2016·Veterinary Clinical Pathology·Kirsty L LightbodyCorrine J Austin
Sep 19, 2018·The American Journal of Tropical Medicine and Hygiene·Jeba Jesudoss ChelladuraiMatthew T Brewer

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