PMID: 590310Nov 14, 1977

Dose dependence of the 14C-aminopyrine breath test. Intrasubject comparison of tracer and pharmacological doses

European Journal of Clinical Pharmacology
I Gikalov, J Bircher

Abstract

Although the aminopyrine breath test has received much attention, the question has not yet been settled whether pharmacological or tracer doses of the drug should be used. Nine volunteers were given 14C-aminopyrine 9 mg/kg or a tracer amount, in a randomized sequence and according to a crossover design. The specific activity of 14CO2 in breath was significantly different only during the first hour. Up to the 8th hour the disappearance of 14CO2 from breath was smaller after the pharmacological (28.5 +/- SD 5.4%/h) than after the tracer dose (36.2 +/- 10.6%/h; p less than 0.05). The over-all disappearance of 14C-atoms from the subjects was significantly slower after the higher dose. In view of the smaller radiation exposure and the decreased risk of agranulocytosis, the use of a tracer dose appears preferable.

References

Oct 1, 1976·Clinical Pharmacology and Therapeutics·J BircherR Preisig
Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·A P AlvaresA Kappas
Apr 4, 1975·European Journal of Clinical Pharmacology·J Raaflaub, U C Dubach

Citations

Dec 1, 1978·European Journal of Clinical Pharmacology·R PlatzerJ Bircher
Jan 1, 1986·International Archives of Occupational and Environmental Health·B DietzeC Brückner
Jan 1, 1987·Fundamental & Clinical Pharmacology·J FeelyA Odumosu
Jun 1, 1993·British Journal of Clinical Pharmacology·J S SidhuB A Smithurst
Jul 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H S Bhatt, B Combes
Jul 1, 1982·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D A SchoellerJ F Schneider
Jan 1, 1982·European Journal of Clinical Pharmacology·U Breyer-PfaffE H Egberts
Apr 1, 1982·European Journal of Clinical Investigation·K O HausteinH Sensing
Oct 1, 1982·European Journal of Pediatrics·E Jäger-RomanH Helge
Jan 25, 2011·Journal of Clinical Pharmacology·Henry Tao Peng, Bob Cheung
Feb 21, 2004·American Journal of Veterinary Research·E Michael MoellerJohn Burr

Related Concepts

Eufibron
Breathalyzer Tests
Carbon Radioisotopes
Dealkylation
Dose-Response Relationship, Drug

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