PMID: 590310Nov 14, 1977

Dose dependence of the 14C-aminopyrine breath test. Intrasubject comparison of tracer and pharmacological doses

European Journal of Clinical Pharmacology
I Gikalov, J Bircher


Although the aminopyrine breath test has received much attention, the question has not yet been settled whether pharmacological or tracer doses of the drug should be used. Nine volunteers were given 14C-aminopyrine 9 mg/kg or a tracer amount, in a randomized sequence and according to a crossover design. The specific activity of 14CO2 in breath was significantly different only during the first hour. Up to the 8th hour the disappearance of 14CO2 from breath was smaller after the pharmacological (28.5 +/- SD 5.4%/h) than after the tracer dose (36.2 +/- 10.6%/h; p less than 0.05). The over-all disappearance of 14C-atoms from the subjects was significantly slower after the higher dose. In view of the smaller radiation exposure and the decreased risk of agranulocytosis, the use of a tracer dose appears preferable.


Oct 1, 1976·Clinical Pharmacology and Therapeutics·J BircherR Preisig
Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·A P AlvaresA Kappas
Apr 4, 1975·European Journal of Clinical Pharmacology·J Raaflaub, U C Dubach


Dec 1, 1978·European Journal of Clinical Pharmacology·R PlatzerJ Bircher
Jan 1, 1986·International Archives of Occupational and Environmental Health·B DietzeC Brückner
Jan 1, 1987·Fundamental & Clinical Pharmacology·J FeelyA Odumosu
Jun 1, 1993·British Journal of Clinical Pharmacology·J S SidhuB A Smithurst
Jul 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H S Bhatt, B Combes
Jul 1, 1982·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D A SchoellerJ F Schneider
Jan 1, 1982·European Journal of Clinical Pharmacology·U Breyer-PfaffE H Egberts
Apr 1, 1982·European Journal of Clinical Investigation·K O HausteinH Sensing
Oct 1, 1982·European Journal of Pediatrics·E Jäger-RomanH Helge
Jan 25, 2011·Journal of Clinical Pharmacology·Henry Tao Peng, Bob Cheung
Feb 21, 2004·American Journal of Veterinary Research·E Michael MoellerJohn Burr

Related Concepts

Breathalyzer Tests
Carbon Radioisotopes
Dose-Response Relationship, Drug

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Related Papers

European Journal of Clinical Pharmacology
V C Ramin, J Bircher
Clinical Pharmacology and Therapeutics
J BircherR Preisig
European Journal of Clinical Pharmacology
K W SomervilleM J Langman
British Journal of Clinical Pharmacology
D A HenryM J Langman
© 2021 Meta ULC. All rights reserved