Dose dependency and individual variability of the lipopolysaccharide-induced bovine acute phase protein response

Journal of Dairy Science
S JacobsenP M H Heegaard

Abstract

In order to investigate the dose dependency and the individual variability of the lipopolysaccharide (LPS)-induced acute phase protein response in cattle, 8 nonlactating, nonpregnant Danish Holstein cows were challenged 3 times each by intravenous injection of increasing doses (10, 100, and 1000 ng/kg, consecutively) of Escherichia coli LPS with 3-wk intervals. All 3 LPS doses resulted in a rapid increase in serum concentrations of haptoglobin and serum amyloid A (SAA) and a decrease in serum concentrations of albumin in all 8 cows. Serum concentrations of acute phase proteins (APP) remained altered for several days after each LPS injection, and their increase or decrease was significantly related to LPS dose. In addition to dose dependency, the response was also dependent on the individual, as APP concentrations differed significantly among cows. To compare APP production in 2 consecutive challenges, individual APP levels after the challenge with 100 ng LPS/kg were correlated to levels attained after the challenge with 1000 ng LPS/kg. Serum amyloid A concentrations correlated between the 2 challenges, whereas haptoglobin concentrations tended to correlate; no correlation could be demonstrated between SAA and haptoglobin concen...Continue Reading

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Citations

Sep 16, 2009·The Veterinary Journal·Billy I SmithLisa Sherman
Jan 4, 2017·Journal of Dairy Science·S K KvideraL H Baumgard
Jan 22, 2013·Journal of Dairy Science·K L ProudfootM A G von Keyserlingk
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Nov 2, 2018·BMC Veterinary Research·Paulina JaworTadeusz Stefaniak
Mar 20, 2020·Biomedical Reports·Rafaat H Khalil, Nabil Al-Humadi
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May 20, 2021·Reproduction in Domestic Animals = Zuchthygiene·Nan WangXu Zhou

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