PMID: 8584433Jan 1, 1996Paper

Dose-dependent alteration of rat cardiac sodium current by isoproterenol: results from direct measurements on multicellular preparations

Pflügers Archiv : European journal of physiology
M KirsteinH Langenfeld

Abstract

Conflicting results have been reported in literature about the influence of beta-adrenergic stimulation on the fast cardiac sodium current (INa+). To elucidate these mechanisms in multicellular preparations we used the loose-patch-clamp technique to evaluate the effect of the beta-adrenergic agonist isoproterenol 1-1000 nmol/l. Isoproterenol enhanced INa+ at all membrane potentials by elevation of the maximal available INa+ . Only at the high concentration of 1 micromol/l was INa+ slightly depressed after depolarizing conditioning clamps. The most marked increase of the maximal available INa+ was 30+/-9% after application of 100 nmol/l isoproterenol. To learn about the mechanisms in view of sodium channel modulation we combined isoproterenol with the sodium channel blocker lidocaine (47 micromol/l). Under these circumstances the effects of both drugs were completely independent. This investigation shows clearly that low concentrations of isoproterenol increase INa+ in multicellular preparations by a gating-independent mechanism.

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Citations

Aug 14, 1999·Progress in Biophysics and Molecular Biology·Y Shimoni
Jul 21, 2009·Acta Pharmacologica Sinica·Hong-wei WangCi-zhen Li
Nov 1, 1996·Pacing and Clinical Electrophysiology : PACE·M KirsteinK Kochsiek
Oct 8, 2009·Circulation. Arrhythmia and Electrophysiology·Augustus O Grant
Nov 14, 2015·Circulation Research·Josefina Ramos-FrancoAriel L Escobar
Oct 27, 2018·Acta Physiologica·Shahid M Iqbal, Rosa Lemmens-Gruber
Dec 24, 1997·Occupational and Environmental Medicine·M van TongerenJ M Harrington
Sep 6, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Maurits A JansenJames A Balschi

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