PMID: 2508162Jan 1, 1989Paper

Dose-dependent and baseline-dependent conditioning with d-amphetamine in the place conditioning paradigm

Psychopharmacology
N L CostelloM Bryda

Abstract

The place conditioning paradigm was used to evaluate the positively reinforcing effects of d-amphetamine. During conditioning, female rats were injected (IP) with saline or one of five doses (0.625-5 mg/kg) of d-amphetamine (d-A) and confined to the initially non-preferred side of the testing apparatus. The highest dose of d-A failed to produce a significant preference. The four middle doses of the drug induced a similar preference. A significant increase from baseline was observed on the 4th post-conditioning test day in the five drug groups and controls when given an injection of 1.5 mg/kg d-A 15 min prior to placement in the chamber. Control and drug groups were separated into high and low initial preference sub-groups. Place preferences were more readily induced by d-A in the subgroups with initially high baseline preferences. These findings as well as those of others led us to conclude that the place conditioning paradigm is a somewhat problematic way of measuring drug reinforcement and that the effects observed may not solely be the result of the conditioning of the drug's reinforcing properties to a particular environment.

References

Dec 1, 1986·Pharmacology, Biochemistry, and Behavior·M T Scoles, S Siegel
Apr 15, 1985·Brain Research·M T Martin-IversonH C Fibiger
Oct 1, 1984·Pharmacology, Biochemistry, and Behavior·M T BardoJ L Neisewander
Jan 1, 1981·Psychopharmacology·H de Wit, J Stewart
Dec 16, 1982·Brain Research·C SpyrakiA G Phillips
May 7, 1982·European Journal of Pharmacology·J B BeckerK A Lorenz

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Citations

Jan 1, 1991·Psychopharmacology·K A TrujilloL Stein
Dec 1, 1989·Pharmacology, Biochemistry, and Behavior·B CostallM B Tyers
Jan 1, 1991·Pharmacology, Biochemistry, and Behavior·M D Schechter
Jan 1, 1995·Neuroscience and Biobehavioral Reviews·M T BardoM J Harris
Jan 1, 1995·Neuroscience and Biobehavioral Reviews·L A Parker
Jul 29, 2003·Learning & Behavior·Linda A Parker
Feb 26, 2016·Pharmacology, Biochemistry, and Behavior·Briana J HempelAnthony L Riley
Dec 4, 2014·Drug and Alcohol Dependence·Heather E KingAnthony L Riley

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