Dose-dependent and time-related stimulus properties of LHRH in male but not in female rats

Psychoneuroendocrinology
R De BeunN E van de Poll

Abstract

Male and female rats (N = 32) were trained to discriminate 5 micrograms/kg LHRH from saline in a two-lever, food-reinforced drug discrimination procedure with injection-session intervals of 15 min or 45 min. When the interval was 15 min, neither males nor females were able to discriminate the stimulus conditions. With an interval of 45 min, LHRH showed sex-dependent stimulus properties. Male, but not female, rats reliably discriminated LHRH from saline within 50 training sessions. In males, generalization tests showed dose-dependent and time-related stimulus effects of LHRH (doses ranged from 62.5 ng/kg to 8 micrograms/kg, and intervals ranged from -15 min to -120 min). The results indicate that LHRH may be an essential part of the stimulus complex in male rats but could not gain control over operant behavior in female rats.

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Citations

Nov 1, 1992·Psychoneuroendocrinology·R De BeunN E van de Poll
Oct 13, 1998·Pharmacology, Biochemistry, and Behavior·S MoraG Díaz-Véliz
Oct 9, 1999·Pharmacology, Biochemistry, and Behavior·R De Beun

Related Concepts

Metazoa
Behavior, Animal
Discrimination (Process of Differentiation)
Discrimination Learning
Dose-Response Relationship, Drug
Gonadorelin Hydrochloride
August Rats
Rats, Laboratory

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