Dose-dependent antinociceptive and sedative effects of epidural romifidine in cattle

The Veterinary Record
M A Marzok, S A El-Khodery

Abstract

The objective of this study was to evaluate the antinociceptive and sedative effects of epidural administration of romifidine in dairy cattle. Twenty-four dairy cows, divided randomly into four groups (three experimental and one control; n=6) received one of three doses of romifidine (30, 40 or 50 μg/kg) diluted in sterile saline (0.9 per cent) to a final volume of 25 ml or an equivalent volume of sterile saline. Antinociception and its anatomical extent was assessed by applying a standard stimulus (needle pin pricks) in different areas and by applying an electrical stimulus to the flank. The antinociceptive effect of romifidine was produced not only in the tail, anus, perineum, vulva and inguinal area but extended up to the coronary band of the hindlimbs and chest areas. Epidural romifidine induced mild-to-moderate sedation at 30 and 40 μg/kg doses and deep sedation at the 50 μg/kg dose. The antinociceptive and sedative effect was dose-dependent in terms of intensity and duration. Thus, epidural administration of romifidine was effective in providing antinociception and sedation in cattle, and can be used in standing flank and udder surgery in cattle.

References

Sep 1, 1991·British Journal of Anaesthesia·J L PedrazA Dominguez-Gil
May 1, 1985·Pharmacology, Biochemistry, and Behavior·T L Yaksh
Mar 27, 2002·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine· AmarpalK Pratap
Jun 18, 2002·The Veterinary Clinics of North America. Equine Practice·Elaine P Robinson, Claudio C Natalini
Sep 24, 2005·Journal of the American Veterinary Medical Association·Inhyung Lee, Haruo Yamada
Aug 28, 2007·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·H MeyerJ Rehage
Jun 17, 2008·The European Journal of Neuroscience·Hideaki IshiiHiroshi Baba
Feb 28, 2014·Veterinary Anaesthesia and Analgesia·Matthew McMillan
Apr 1, 2002·Veterinary Anaesthesia and Analgesia·Tamara L GrubbL Dean Lamb
Jul 1, 2001·Veterinary Anaesthesia and Analgesia·Inhyung LeeHaruo Yamada

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.