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Dose-dependent benzalkonium chloride toxicity imparts ocular surface epithelial changes with features of dry eye disease

The Ocular Surface

Nov 20, 2019

Richard ZhangNick Di Girolamo

Abstract

Inclusion of the preservative benzalkonium chloride (BAC) in ophthalmic solutions is prevalent, despite the noted potential for exacerbating dry eye disease (DED). Whilst studies incorporating BAC have assessed its' effects as a mouse model of DED, the impact on limbal epithelia is unde...read more

Mentioned in this Paper

Study
Necrosis
Treatment Protocols
Histology Procedure
C57BL/6 Mouse
KRT14
Benzalkonium Chloride
Toxic Effect
Corneal Epithelial Cell
Structure of Intestinal Epithelium
1
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Dose-dependent benzalkonium chloride toxicity imparts ocular surface epithelial changes with features of dry eye disease

The Ocular Surface

Nov 20, 2019

Richard ZhangNick Di Girolamo

PMID: 31740391

DOI: 10.1016/j.jtos.2019.11.006

Abstract

Inclusion of the preservative benzalkonium chloride (BAC) in ophthalmic solutions is prevalent, despite the noted potential for exacerbating dry eye disease (DED). Whilst studies incorporating BAC have assessed its' effects as a mouse model of DED, the impact on limbal epithelia is unde...read more

Mentioned in this Paper

Study
Necrosis
Treatment Protocols
Histology Procedure
C57BL/6 Mouse
KRT14
Benzalkonium Chloride
Toxic Effect
Corneal Epithelial Cell
Structure of Intestinal Epithelium
1

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