Dose-dependent cytotoxicity of bismuth nanoparticles produced by LASiS in a reference mammalian cell line BALB/c 3T3

Toxicology in Vitro : an International Journal Published in Association with BIBRA
Thamile Luciane ReusBruno Dallagiovanna

Abstract

Nanoparticles (NPs) have emerged as new potential tools for many applications in previous years. Among all types of NPs, bismuth NPs (BiNPs) have a very low cost and potential for many applications, ranging from medicine to industry. Although the toxic effects of bismuth have been studied, little is known about its toxicity at the nanoscale level. Therefore, in this study, we aimed to investigate the cytotoxic effects of BiNPs produced by laser ablation synthesis in solution (LASiS) in a reference mammalian cell line to evaluate their cytotoxicity (BALB/c 3 T3 cells). We also stabilized BiNPs in two different solutions: culture medium supplemented with fetal bovine serum (FBS) and bovine serum albumin (BSA). The cytotoxicity of BiNPs in culture medium (IC50:28.51 ± 9.96 μg/ml) and in BSA (IC50:25.54 ± 8.37 μg/ml) was assessed, and they were not significantly different. Second, the LD50 was predicted, and BiNPs were estimated as GHS class 4. We also found that cell death occurs due to apoptosis. By evaluating the interaction between BiNPs and cells at ultrastructural level, we suggest that cell death occurs once BiNPs are internalized. Additionally, we suggest that BiNPs cause cell damage because myelin figures were found inside...Continue Reading

Citations

May 15, 2020·MethodsX·Roberto Vazquez-MunozJose L Lopez-Ribot
Nov 1, 2020·Journal of Materials Science. Materials in Medicine·Jessica Zablocki da LuzFrancisco Filipak Neto
Apr 23, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mya Mya KhinXiao Hu

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