Dose-dependent effect of intrathecal dexmedetomidine on isobaric ropivacaine in spinal anesthesia for abdominal hysterectomy: Effect on block characteristics and hemodynamics

Journal of Anaesthesiology, Clinical Pharmacology
Udita NaithaniD S Pradeep

Abstract

Effect of intrathecal dexmedetomidine as an adjuvant to isobaric ropivacaine in spinal anesthesia for abdominal hysterectomy is not much investigated. The objective was to assess the dose dependent effect of dexmedetomidine (3 mcg vs 5 mcg) as an adjunct to isobaric ropivacaine in spinal anesthesia. Forty selected female patients were randomized to receive intrathecal 0.5% isobaric ropivacaine (15 mg) with dexmedetomidine 3 mcg (Group D3) or 5 mcg (Group D5) in spinal anesthesia for abdominal hysterectomy. Block characteristics, hemodynamic changes, postoperative analgesia, and adverse effects were compared. Both groups were comparable regarding sensory-motor block characteristics and postoperative analgesia (P > 0.05). Four (10%) patients of Group D5 and 5 (12.5%) of Group D3 could not achieve desired T6 sensory level and Bromage score of 3(complete motor block) hence were converted to general anesthesia at the outset. Nine (22.5%) patients each in both groups required ketamine supplementation (0.5 mg/kg) for intraoperative pain at the time of uterine manipulation. Incidence of hypotension was comparable (55.56% in Group D5 and 37.14% in Group D3, P = 0.11), but this occurred significantly earlier in Group D5, P < 0.001. Sedat...Continue Reading

References

Oct 25, 2000·Anesthesiology·T Kamibayashi, M Maze
Sep 28, 2001·British Journal of Anaesthesia·J B WhitesideJ A Wildsmith
Sep 29, 2001·British Journal of Anaesthesia·J E HallT J Ebert
Sep 7, 2004·British Journal of Anaesthesia·H KallioP H Rosenberg
Sep 24, 2004·Anesthesia and Analgesia·Stephan StrebelChristoph H Kindler
Jan 25, 2006·Acta Anaesthesiologica Scandinavica·G E KanaziA S Baraka
Mar 3, 2007·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Jean-Stéphane DavidPierre-Yves Gueugniaud
Jun 30, 2011·Indian Journal of Anaesthesia·Gaurav Kuthiala, Geeta Chaudhary
Oct 21, 2011·Indian Journal of Anaesthesia·Rajni GuptaSanjiv Kumar
Dec 14, 2011·Intensive Care Medicine·Nelson H BurbanoRicardo A Munoz

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Methods Mentioned

BETA
hysterectomy
sedation
hysterectomies

Software Mentioned

SPSS

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