Dose-dependent effect of smoking on risk of coronary heart disease, heart failure and stroke in individuals with type 1 diabetes

Diabetologia
Maija FeodoroffFinnDiane Study Group

Abstract

The aim of this study was to assess the potential dose-dependent effects of smoking on the risk of CHD, heart failure and stroke in individuals with type 1 diabetes. The study included 4506 individuals with type 1 diabetes who were participating in the Finnish Diabetic Nephropathy (FinnDiane) study. Intensity of smoking was estimated by packs per day and cumulative smoking by pack-years. Cox regression analyses were used to estimate the risk of incident CHD, heart failure or stroke during follow-up. One pack per day significantly increased the risk of incident CHD in current smokers compared with never smokers (HR 1.45 [95% CI 1.15, 1.84]), after adjustment for age, sex, HbA1c, hypertension, duration of diabetes and BMI. The risk of CHD in former smokers was similar to the risk in never smokers. The risk of incident heart failure was 1.43 (95% CI 1.03, 1.97) in current smokers per one pack per day and 1.37 (95% CI 1.05, 1.77) in former smokers, while the risk of incident stroke was 1.70 (95% CI 1.26, 2.29) and 1.49 (95% CI 1.14, 1.93), respectively. After further adjustments for lipids, however, the difference in the risk of heart failure in current and former smokers was no longer significant. Cumulative smoking data were simi...Continue Reading

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Citations

Apr 3, 2020·Diabetes/metabolism Research and Reviews·C ViñalsA J Amor
Nov 28, 2019·Journal of Tropical Pediatrics·Tugba Sismanlar EyubogluIsıl Irem Budakoglu
Jun 20, 2020·American Journal of Epidemiology·John M LachinBarbara Braffett
Aug 1, 2019·International Journal of Environmental Research and Public Health·Hyeonju Lee, Youn-Jung Son
May 28, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Tonet Serés-NoriegaAntonio J Amor

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