Dose-dependent effects of fish oil on cardio-metabolic biomarkers in healthy middle-aged and elderly Chinese people: a double-blind randomized controlled trial

Food & Function
Jia SongLimei Mao

Abstract

n-3PUFA consumption has been widely accepted as a nutritional strategy for the secondary prevention of cardiovascular events in patients at high risk of cardiovascular disease (CVD), but little is known about the dose-response relationship between dietary n-3PUFA and serum biomarkers associated with cardiovascular health in the general population. The present study involved a 12-week double-blind, randomized controlled trial to explore the effects of fish oil with different doses (0.31, 0.62 and 1.24 g d-1 of EPA and DHA) on serum fatty acids and cardio-metabolic biomarkers including adiponectin, inflammatory markers, lipid profiles and fasting glucose in healthy middle-aged and elderly Chinese people. 240 volunteers met our inclusion criteria. A total of 39 subjects dropped out and 201 finally completed the intervention. No significant differences in baseline characteristics and daily intakes of dietary nutrients were detected among all groups. After a 12-week intervention, fish oil dose-dependently enhanced serum EPA, DHA, n-3PUFA and adiponectin (except for 0.31 g d-1), but decreased serum n-6/n-3PUFA, TG and fasting glucose. Changes in the above indicators from the baseline to week 12 in fish oil groups significantly differ...Continue Reading

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Citations

Jan 24, 2020·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Artur BjelicaJelena Cvejić
Feb 20, 2020·Nutrition Reviews·Myeong Gyu KimKyungim Kim
May 1, 2021·Nutrients·Justyna JaniszewskaDorota Szostak-Węgierek
May 11, 2021·Critical Reviews in Food Science and Nutrition·Kristin KruegerMarietta Zille

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ELISA

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SPSS

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