PMID: 9444314Jan 28, 1998Paper

Dose-dependent effects on the disposition of monomethylarsonic acid and dimethylarsinic acid in the mouse after intravenous administration

Journal of Toxicology and Environmental Health. Part a
M F Hughes, E M Kenyon

Abstract

The organic arsenicals monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) are the primary metabolites of inorganic arsenic, a known human carcinogen. The objective of this study was to examine if dose would affect the excretion and terminal tissue disposition of MMA and DMA in the mouse. 14C-MMA (4.84 and 484 mumol/kg) and -DMA (8.04 and 804 mumol/kg) were administered to female mice via the tail vein. The mice were placed in metabolism cages for collection of urine (1, 2, 4, 8, 12, and 24 h) and feces (24 h). The animals were then sacrificed at 24 h and tissues were removed and analyzed for radioactivity. The urine was also analyzed for parent compound and metabolites. Urinary excretion of MMA- and DMA-derived radioactivity predominated over fecal excretion. Dose did not affect the overall urinary excretion of both compounds. However, fecal excretion was significantly lower in the low-dose MMA-treated animals as opposed to in the high-dose group, whereas in the high-dose DMA-treated group excretion was lower than in the low-dose DMA group. The retention of radioactivity was low (< 2% of dose) and the distribution pattern similar for both compounds, with carcass > liver > kidney > lung. The concentration of radioactivi...Continue Reading

Citations

Sep 19, 2003·Toxicology and Applied Pharmacology·Michael F HughesDavid J Thomas
Dec 31, 2002·Toxicology·Marie Vahter
Oct 16, 1999·Toxicology·M F HughesD J Thomas
Feb 26, 2010·International Journal of Environmental Health Research·Luigi VimercatiGiorgio Assennato
Dec 12, 2003·Journal of Toxicology and Environmental Health. Part a·P Robinan GentryHarvey J Clewell
Apr 1, 2005·Journal of Toxicology and Environmental Health. Part a·P Robinan GentryHarvey J Clewell
Mar 17, 2007·Journal of Toxicology and Environmental Health. Part a·Craig SteinmausAllan H Smith
Apr 24, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Marina V EvansHisham A El-Masri
Jul 20, 2007·Environmental Health Perspectives·Anna-Lena LindbergMarie Vahter
Sep 6, 2005·Environmental Health Perspectives·Craig SteinmausAllan H Smith
Nov 10, 2006·Regulatory Toxicology and Pharmacology : RTP·Jonathan Borak, H Dean Hosgood
Jul 22, 2015·Journal of Pharmacokinetics and Pharmacodynamics·Ramon I GarciaR Woodrow Setzer
Sep 10, 2011·Biomedical Chromatography : BMC·Pradeep AlavaTom Van de Wiele
Feb 16, 2011·Journal of Applied Toxicology : JAT·K JomovaM Valko
Oct 19, 2011·Toxicology Mechanisms and Methods·Eliud A García-MontalvoLuz M Del Razo
May 12, 2006·Journal of Occupational and Environmental Medicine·Craig SteinmausAllan H Smith
Feb 28, 2013·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Pradeep AlavaTom R Van de Wiele
Dec 18, 2019·Environmental Science and Pollution Research International·Chad Joseph BartholomewTing Guo
Mar 22, 2019·Scientific Reports·Ping ZhouShicheng Wei

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