Dose-dependent improvement of myoclonic hyperkinesia due to Valproic acid in eight Huntington's Disease patients: a case series

BMC Neurology
Carsten SaftJuergen E Andrich

Abstract

Chorea in Huntington's Disease (HD) is usually treated with antidopaminergic neuroleptics like haloperidol, olanzapine and tiaprid or dopamine depleting drugs like tetrabenazine. Some patients with hyperkinesia, however, react to treatment with antidopaminergic drugs by developing extrapyramidal side effects. In earlier studies valproic acid showed no beneficial effect on involuntary choreatic movements. Myoclonus is rare in HD and is often overseen or misdiagnosed as chorea. In this report, we present eight patients whose main symptom is myoclonic hyperkinesia. All patients were treated with valproic acid and scored by using the Unified Huntington's Disease Rating Scale (UHDRS) motor score before and after treatment. In addition to this, two patients agreed to be videotaped. In seven patients myoclonus and, therefore the UHDRS motor score improved in a dose dependent manner. In three of these patients antidopaminergic medication could be reduced. In the rare subgroup of HD patients suffering from myoclonic hyperkinesia, valproic acid is a possible alternative treatment.

References

Nov 6, 1976·British Medical Journal·J A LenmanM J Turnbull
Jan 1, 1976·Clinical Neurology and Neurosurgery·B K TanM F Zee
May 1, 1977·Archives of Neurology·I PearceM J Pearce
Mar 1, 1978·The American Journal of Psychiatry·G R SymingtonF J Vajda
Oct 1, 1977·Annals of Neurology·R SchwarczJ T Coyle
Feb 1, 1991·Annals of Neurology·C M VogelA B Young
Aug 1, 1985·Acta Neurologica Scandinavica·L Gram, K D Bentsen
Jun 1, 1980·Italian Journal of Neurological Sciences·P Previdi, R Borgonovi
Apr 1, 1980·Clinical EEG (electroencephalography)·S KereshiK S Richardson
Nov 1, 1994·Movement Disorders : Official Journal of the Movement Disorder Society·P D ThompsonC D Marsden
Apr 1, 1993·Movement Disorders : Official Journal of the Movement Disorder Society·F CarellaF Girotti
Mar 1, 1996·Movement Disorders : Official Journal of the Movement Disorder Society
Jul 1, 1997·Pediatric Neurology·S SieslingR A Roos
Dec 17, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·J N Caviness, M Kurth
Nov 25, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·S SieslingR A Roos
Jan 15, 2000·Neurology·R Sánchez-PernauteK L Leenders
Sep 30, 2000·The New England Journal of Medicine·V E GroveG T DeVaney
Aug 29, 2001·Neurology·J S PaulsenUNKNOWN Huntington Study Group
Aug 14, 2002·Current Medicinal Chemistry·Roman A BlahetaJindrich Cinatl
Oct 18, 2002·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·F J E Vajda
Jan 24, 2003·Journal of Molecular Neuroscience : MN·Rebekah Loy, Pierre N Tariot
Dec 16, 2003·Journal of Neurology·Carsten SaftThomas Müller
Sep 10, 2004·Journal of Neural Transmission. Supplementum·C SaftTh Müller
Nov 17, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Cecilie MorlandBjørnar Hassel
Dec 8, 2004·The European Journal of Neuroscience·Fuminobu SugaiSaburo Sakoda
Apr 14, 2005·The Psychiatric Clinics of North America·Diane C Lagace, Amelia J Eisch

❮ Previous
Next ❯

Citations

Apr 9, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Octavian R Adam, Joseph Jankovic
Jan 10, 2013·Pharmacological Reviews·Chi-Tso ChiuDe-Maw Chuang
Mar 14, 2013·Therapeutic Advances in Neurological Disorders·Jean-Marc Burgunder
Dec 1, 2011·Epigenomics·Steven G Gray
Jan 20, 2011·The Nurse Practitioner·Angela CumminsJulianne S Collins
Jan 31, 2008·Expert Opinion on Investigational Drugs·Eric HahnenIngmar Blümcke
Jul 25, 2012·Neuroscience Research·R Lalonde, C Strazielle
Aug 10, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sorabh Sharma, Rajeev Taliyan
Nov 16, 2014·Current Neurology and Neuroscience Reports·Kelly Mills, Zoltan Mari
Mar 23, 2017·Current Neurology and Neuroscience Reports·Kara J WyantPraveen Dayalu
Aug 29, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Annie Killoran, Kevin M Biglan
Jun 27, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Wendy PhillipsRoger A Barker
Jul 21, 2010·CNS Neuroscience & Therapeutics·Steven G Gray
Jul 10, 2009·The Cochrane Database of Systematic Reviews·Tiago MestreCristina Sampaio
Dec 18, 2009·British Journal of Pharmacology·Pritika Narayan, Mike Dragunow
Dec 17, 2014·Journal of Neural Transmission·Carsten SaftChristos Krogias
Feb 9, 2012·Current Treatment Options in Neurology·Annie Killoran, Kevin M Biglan
Nov 10, 2017·Expert Review of Neurotherapeutics·H Bashir, J Jankovic
Jun 19, 2012·Clinical Epigenetics·Steven G Gray
Jul 25, 2019·Frontiers in Neurology·Anne-Catherine Bachoud-LéviJean-Marc Burgunder
Sep 11, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ashley B Pena, John N Caviness
Aug 11, 2020·Movement Disorders Clinical Practice·Daniel RichterLars Tönges
Mar 23, 2018·Journal of Huntington's Disease·Carsten SaftKlaus Seppi
May 18, 2020·Journal of Huntington's Disease·Nicholas E KaragasErin Furr Stimming
May 6, 2020·Fortschritte der Neurologie-Psychiatrie·Charlotte ThielsThomas Lücke
Aug 29, 2021·Pharmaceuticals·Marcin JanowskiAleksandra Pękowska

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Related Papers

La semaine des hôpitaux : organe fondé par l'Association d'enseignement médical des hôpitaux de Paris
H Allain, O Sabouraud
Expert Opinion on Pharmacotherapy
Alfonso Fasano, Anna Rita Bentivoglio
Neurología : publicación oficial de la Sociedad Española de Neurología
S Giménez-Roldán, D Mateo
© 2021 Meta ULC. All rights reserved