Abstract
Recently, we reported inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) plus benzo(a)pyrene (BaP)-induced lung tumorigenesis in A/J mice by indole-3-carbinol (I3C; 112 micromol/g diet) administered beginning at 50% in the carcinogen treatment phase. In this study, we examined the dose-dependent and postcarcinogen tumor-inhibitory activities of I3C. A mixture of NNK plus BaP (2 micromol each) administered by gavage as eight biweekly doses caused 21.1 +/- 5.2 lung tumors per mouse. Carcinogen-treated mice given diets containing I3C at 1, 10, 30, 71, and 112 micromol/g, beginning at 50% in the carcinogen treatment phase, had 17.9 +/- 6.1, 10.4 +/- 3.7, 9.8 +/- 5.1, 5.2 +/- 4.0, and 2.5 +/- 2.4 lung tumors per mouse, corresponding to reductions by 15%, 51%, 53%, 75%, and 88%, respectively. All reductions, except at the lowest dose level (1 micromol I3C/g diet), were significant (P < 0.001). Similarly, administration of I3C (112 micromol/g diet) beginning 1 week after the last dose of the carcinogen significantly reduced NNK plus BaP-induced lung tumor multiplicity to 5.6 +/- 3.5, corresponding to a reduction by 74%. Analyses of cell proliferation and apoptosis markers revealed that I3C reduced the number of Ki-67-p...Continue Reading
References
Aug 28, 1992·Chemico-biological Interactions·J Y Park, L F Bjeldanes
Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·L F BjeldanesC A Bradfield
Apr 1, 1991·Carcinogenesis·J J JangJ H Bae
Jan 1, 1983·Carcinogenesis·S S HechtA Castonguay
Nov 1, 1993·The Journal of Nutrition·P G ReevesG C Fahey
Nov 5, 1997·Cell·S R DattaM E Greenberg
May 5, 1998·Chemico-biological Interactions·R H Dashwood
Jun 24, 1998·Chemical Research in Toxicology·S S Hecht
Jun 17, 1998·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·C A RosenH L Bradlow
Jul 21, 1999·Journal of the National Cancer Institute·S S Hecht
Aug 6, 2000·Gynecologic Oncology·M C BellJ M Mathis
Jun 8, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·A M Malkinson
Jul 17, 2001·Chemical Research in Toxicology·D HoffmannK El-Bayoumy
Aug 30, 2001·Nutrition and Cancer·C C ConawayF L Chung
Dec 12, 2001·The Journal of Nutrition·D Z ChenT H Carter
Mar 16, 2002·Carcinogenesis·Kenneth T Bogen, Hanspeter Witschi
Jan 15, 2003·Annual Review of Medicine·Stephen D HurstingJ Carl Barrett
Dec 3, 2003·Oncogene·Allison E BonnerMing You
Aug 7, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mark J AndertonMarion L Williams
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Apr 9, 2005·Inhalation Toxicology·W StinnH-J Haussmann
Aug 17, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Gregory A ReedAryeh Hurwitz
May 18, 2006·Carcinogenesis·Zhen YuDavid E Williams
Jul 10, 2007·Cancer Research·Fekadu KassieStephen S Hecht
Aug 19, 2007·Cancer Research·Yan WengXinxin Ding
Sep 22, 2007·The Journal of Nutrition·Geoffrey K MaiyohAndre G Theriault
Oct 17, 2007·Environmental Health Perspectives·Christopher R CederrothSerge Nef
Dec 8, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Einat SouliShmuel Yannai
Jan 15, 2008·Carcinogenesis·Fekadu KassieStephen S Hecht
Jan 22, 2008·Carcinogenesis·Volker M ArltDavid H Phillips
Feb 22, 2008·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Citations
Jun 25, 2009·Nature Reviews. Cancer·Stephen S HechtDorothy K Hatsukami
Jul 25, 2009·Carcinogenesis·Fekadu KassieStephen S Hecht
Jul 7, 2010·Carcinogenesis·Fekadu KassieStephen S Hecht
Jan 29, 2011·Carcinogenesis·Abaineh DagneFekadu Kassie
Dec 24, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Regan M Memmott, Phillip A Dennis
Aug 6, 2010·PloS One·Junya FujimotoReuben Lotan
Nov 22, 2013·Reproductive Toxicology·Joyce Zalotti BrandtWellerson Rodrigo Scarano
Nov 12, 2010·Toxicology Mechanisms and Methods·Yau-Hung ChenYun-Hsin Wang
Apr 10, 2013·Toxicology and Applied Pharmacology·Lyndsey E ShoreyDavid E Williams
Jul 20, 2011·Cancer Letters·Xuemin QianFekadu Kassie
Aug 13, 2011·Molecular Carcinogenesis·Tien-Yuan WuAh-Ng Tong Kong
Feb 20, 2010·Microscopy Research and Technique·Kameswaran RavichandranRamanibai Ravichandran
Jun 5, 2015·Acta Biochimica Et Biophysica Sinica·Guang-Zhe GeCeshi Chen
Apr 22, 2015·Carcinogenesis·Jung Min SongFekadu Kassie
Jun 28, 2014·Cancer Biology & Therapy·Lan ChenHeshan Sam Zhou
Feb 4, 2016·Molecular Nutrition & Food Research·Naomi FujiokaStephen S Hecht
Jul 6, 2016·Molecular Carcinogenesis·Rasika R HudlikarManoj B Mahimkar
Sep 1, 2016·Journal of Dietary Supplements·Arnetta FletcherThomas T Y Wang
Jun 10, 2017·Seminars in Cancer Biology·Ada PopoloLuca Rastrelli
Mar 26, 2010·International Journal of Toxicology·Wei ZhuXingfen Yang
Apr 2, 2020·Nutrients·Yanbei WuAllen D Smith
Oct 21, 2020·Nutrients·Yanbei WuThomas T Y Wang
Aug 20, 2016·Cancer Prevention Research·Naomi FujiokaStephen S Hecht
Dec 18, 2019·International Journal of Radiation Biology·Vinita ChauhanRobert Stainforth