Dose-Dependent Inhibitory Effects of Cilostazol on Delayed Cerebral Infarction After Aneurysmal Subarachnoid Hemorrhage

Translational Stroke Research
Hidenori SuzukiNaoki Toma

Abstract

Cilostazol is a selective inhibitor of phosphodiesterase type III that downregulates tenascin-C (TNC), a matricellular protein, which may cause delayed cerebral infarction after aneurysmal subarachnoid hemorrhage (SAH). The authors increased the dosage and evaluated the dose-dependent effects of cilostazol on delayed cerebral infarction and outcomes in SAH patients. This was a retrospective cohort study in a single center. One hundred fifty-six consecutive SAH patients including 67 patients of admission World Federation of Neurological Surgeons grades IV-V who underwent aneurysmal obliteration within 48 h post-SAH from 2007 to 2017 were analyzed. Cilostazol (0 to 300 mg/day) was administered from 1-day post-clipping or post-coiling to day 14 or later. Cilostazol treatment dose-dependently decreased delayed cerebral infarction and tended to improve outcomes, although cilostazol did not affect other outcome measures including angiographic vasospasm. On multivariate analyses, 300 mg/day (100 mg three times) cilostazol independently decreased delayed cerebral infarction and improved 3-month outcomes, but other regimens including 200 mg/day (100 mg twice) cilostazol were not independent prognostic factors. Propensity score-matched a...Continue Reading

References

Jul 11, 2006·Neurosurgery·Jennifer A FronteraStephan A Mayer
Mar 31, 2010·Neurological Research·Akio NishinoToshiki Yoshimine
Jun 17, 2011·Cerebrovascular Diseases·Satoshi SuzukiIwao Takeshita
Aug 25, 2011·Journal of Neurosurgical Anesthesiology·Hidenori SuzukiWaro Taki
Jul 31, 2013·Translational Stroke Research·Mutsumi FujiiJohn H Zhang
Dec 17, 2014·Translational Stroke Research·Hidenori Suzuki
Apr 14, 2016·Neural Regeneration Research·Hidenori Suzuki, Fumihiro Kawakita
Aug 6, 2016·Journal of Neurosurgery·Yoshinari NakatsukaUNKNOWN , on behalf of the Prospective Registry for Searching Mediators of Neurovascular Events After Aneurysmal Subarachnoid Hemorr
Sep 18, 2016·Lancet·R Loch Macdonald, Tom A Schweizer
Mar 1, 2017·Stroke; a Journal of Cerebral Circulation·Lei LiuHidenori Suzuki
Oct 19, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yong-Ke ZhengWen-Hua Yu
Jul 22, 2018·Neural Regeneration Research·Hidenori SuzukiFumihiro Kawakita

❮ Previous
Next ❯

Citations

Sep 23, 2018·Journal of Neuroscience Research·Hidenori SuzukiMasato Shiba
Feb 26, 2019·Neural Regeneration Research·Hideki Kanamaru, Hidenori Suzuki
Jan 13, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Hideki KanamaruUNKNOWN pSEED group
Dec 12, 2018·Neural Regeneration Research·Masato Shiba, Hidenori Suzuki
Feb 9, 2021·Frontiers in Immunology·Takeshi Okada, Hidenori Suzuki
Apr 18, 2020·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Hideki KanamaruUNKNOWN pSEED group

❮ Previous
Next ❯

Methods Mentioned

BETA
percutaneous transluminal angioplasty
ELISA

Software Mentioned

R
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nihon rinsho. Japanese journal of clinical medicine
Haruo Hirayama
Nihon rinsho. Japanese journal of clinical medicine
Teruo Inoue
American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Yoshitsugu NakamuraShigeki Arawaka
© 2022 Meta ULC. All rights reserved