Dose-dependent neurologic abnormalities in workers exposed to 1-bromopropane

Journal of Occupational and Environmental Medicine
Weihua LiGaku Ichihara

Abstract

To investigate the health effects of 1-bromopropane (1-BP) and its dose-dependency in 1-BP production factories in China. Data of 60 female and 26 male workers in three 1-BP factories and the same number of age-, sex-, and region-matched controls were interviewed and examined. The time-weighed average exposure levels of individual workers were estimated. Regression analysis on exposure level showed dose-dependent increase in the distal latency of tibial nerve, threshold for vibration sense in toes, lactate dehydrogenase, thyroid stimulating hormone, and follicle stimulating hormone in female workers. The analysis also showed dose-dependent decrease in sensory nerve conduction velocity of the sural nerve, red blood cell, and hematocrit in female workers. The results indicate that exposure to 1-BP induces dose-dependent neurotoxicity in female workers.

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Citations

Jun 19, 2013·Archives of Pharmacal Research·Hyung Min JeongKwang Youl Lee
Aug 13, 2011·Journal of Toxicology and Environmental Health. Part a·H Frederick FraschAna M Barbero
Dec 3, 2014·Toxicology and Applied Pharmacology·Zhenlie HuangGaku Ichihara
Feb 24, 2016·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Patricia I Mathias, Clayton B'hymer
Sep 20, 2011·Toxicology and Applied Pharmacology·Zhenlie HuangGaku Ichihara
Apr 30, 2011·Toxicology·Sahabudeen Sheik MohideenShoji Nakamura
Feb 23, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Eun Hee HanHye Gwang Jeong
Apr 26, 2016·Journal of Occupational Health·Toru IshidaoHajime Hori
Jul 28, 2016·Journal of Applied Toxicology : JAT·Fen HuangGaku Ichihara
Apr 24, 2012·Toxicology Mechanisms and Methods·Patricia I MathiasClayton B'hymer
Nov 28, 2012·Journal of Occupational Health·Sahabudeen Sheik MohideenGaku Ichihara
Jun 12, 2019·Toxicologic Pathology·William M Valentine
Jul 9, 2011·Journal of Occupational and Environmental Medicine·Carr J SmithTodd Stedeford
Sep 15, 2011·Journal of Occupational and Environmental Medicine·Gaku IchiharaYasuhiro Takeuchi
Aug 4, 2016·Toxicology Research·Cai ZongGaku Ichihara

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